ABSTRACT The Patient-Reported Outcomes, Community Engagement, and Language (PRO-CEL) Core enhances the objectives of the Center's research programs by supporting the array of MSK investigators who wish to capture self-reported information from culturally varied patients, caregivers, clinical staff, and community members. The faculty of the PRO-CEL Core are nationally recognized social and behavioral scientists and community outreach experts who provide technical assistance to all users throughout multiple stages of research, including grant and protocol development, research study assistant and support staff training, and results dissemination. The PRO-CEL Core aims to (1) provide research consultation support and training in the selection and/or design of specific patient-reported outcome (PRO) survey tools, as well as measures to collect data from other key stakeholders (e.g., caregivers, physicians, nurses, community members at high risk of cancer); (2) assist investigators in the design, implementation and analysis of all aspects of qualitative research; (3) support MSK investigators who wish to incorporate PRO, qualitative, and/or community outreach and participation research methods into peer-reviewed funding applications; and (4) provide methodological support for clinical trial, behavioral, and population-based research that seeks to work with community or understudied populations. The services provided by the PRO-CEL Core have supported the research of 123 MSK investigators in the past year, and during the past grant period the work of this Core Facility has contributed to 898 peer-reviewed publications.