PROJECT SUMMARY/ABSTRACT – CANCER CONTROL AND SURVIVORSHIP PROGRAM The overarching goal of the Cancer Control and Survivorship Program (CCSP) is to conduct innovative clinical, genetic, and observational research and translate the findings into effective strategies to avert or mitigate treatment-related complications and improve the quality of life of childhood cancer survivors. Gregory Armstrong, MD, MSCE, is a physician–scientist and Chair of the Department of Epidemiology & Cancer Control. Kirsten Ness, PT, PhD, is a member of the Department of Epidemiology & Cancer Control and holds the Endowed Chair in Cancer Survivorship. Together, Armstrong and Ness lead the CCSP. Their leadership roles in two NCI-funded cohorts, the Childhood Cancer Survivor Study, and the St. Jude Lifetime Cohort Study facilitate discoveries characterizing the magnitude and scope of morbidity of the childhood cancer survivorship experience. They also lead: (1) a weekly CCSP-wide integrated meeting to identify high-priority research opportunities, and (2) strategic planning with other Program Leaders (quarterly) and the Cancer Center Director and Administration (quarterly) to leverage infrastructure for collaborative investigations, particularly for early career members. CCSP research has influenced the design of contemporary pediatric cancer treatment strategies and provided critical data to guide health surveillance and health-preserving interventions for long-term survivors. The CCSP’s infrastructure, which was designed to support and enhance research conducted by Program members reflect St. Jude Comprehensive Cancer Center resources. The design and conduct of innovative research are facilitated by seven discipline-specific CCSP Working Groups that meet biweekly or monthly: Behavioral–Psychosocial, Cardiopulmonary–Renal, Endocrine–Reproductive, Epidemiology–Biostatistics–Global Outcomes, Genetics– Genomics, Health Services (added in 2022), and Neurosciences. CCSP members have participate