# Rapid Free-Breathing Self-Gated Spiral Pulse Sequences for Simultaneous Cine and T1 mapping

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $515,589

## Abstract

7. Project Summary
 Heart failure (HF) is a major public health concern with an estimated 6.2 million Americans suffering
from HF and greater than 1 million new cases per year. Patients with HF have significantly reduced quality of
life and are at high risk for hospitalization and adverse cardiovascular outcomes. There is a growing
recognition of the clinical utility of cardiac magnetic resonance imaging (CMR) for assessing patients with HF.
While there is growing utilization of CMR for evaluation of HF, there remain a number of barriers to widespread
acceptance and utilization of CMR for this application. Current clinical studies take 40 min to an hour and
require the patient to complete about 40 separate breath-holds of 10-15 second duration. There is strong
potential to improve the clinical utility of CMR in HF by creating simplified and robust free-breathing, non-ECG
gated techniques, which are straightforward to perform. This would also improve the patient experience by
shortening the study and eliminating the need for breath-holding, which is particularly difficult for HF patients.
 To address these limitations of current clinical techniques, we propose to develop and validate a
technique, Cine And T1 mapping SPiral Acquisition with Respiratory and Cardiac Self-gating (CAT-SPARCS),
which will simultaneously perform cine and T1 mapping in a <5 minute FB non-ECG gated acquisition.
Application of this technique pre and post contrast will enable a comprehensive assessment of cardiac function,
Native T1, LGE and ECV in under 15-minutes. The specific aims of this proposal are (1) to develop a 2D CAT-
SPARCS technique to simultaneously acquire cine, T1 maps and LGE images during a free-breathing cardiac
self-gated acquisition, (2) to extend the 2D CAT-SPARCS to provide whole heart simultaneous acquisition of
cine, T1 mapping and LGE images using simultaneous multi-slice (SMS) and 3D spiral acquisition techniques,
and (3) to validate the CAT-SPARCS technique against the clinical gold standard breath-held ECG-gated clinical
techniques in normal subjects and patients being evaluated for HF. Successful completion of this grant will result
in the development and validation of a highly efficient technique for simultaneous T1 mapping and cine imaging
which will demonstrate high accuracy and repeatability significantly shortening the CMR examination.

## Key facts

- **NIH application ID:** 11321063
- **Project number:** 7R01HL155962-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Michael Salerno
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $515,589
- **Award type:** 7
- **Project period:** 2021-05-01 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11321063

## Citation

> US National Institutes of Health, RePORTER application 11321063, Rapid Free-Breathing Self-Gated Spiral Pulse Sequences for Simultaneous Cine and T1 mapping (7R01HL155962-05). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/11321063. Licensed CC0.

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