# Non-Invasive Carotid Artery Measurements for Continuous Intracranial Pressure Monitoring

> **NIH HL F30** · UNIVERSITY OF CALIFORNIA-IRVINE · 2026 · $55,114

## Abstract

PROJECT SUMMARY
Continuous intracranial pressure (ICP) monitoring is an important surveillance tool for critically ill neurologic
patients that provides
critical insights on disease severity for guiding medical management
. However,
ICP
monitoring requires a highly invasive procedures that incurs risks for intracranial hemorrhage and infection.24–28
Thus, the clinical indications for ICP monitoring are a topic of debate and up to 50% of traumatic brain injury
patients who fulfill recommendation criteria for an ICP monitor never receive it.22 Moreover, nearly half of patients
admitted to the Neuro-Intensive Care Unit (Neuro-ICU) without an ICP monitor go on to later develop elevated
ICP.1 Unfortunately, even eligible patients are only provided ICP monitoring while in the Neuro-ICU. After
adequate recovery, they are transferred to a step-down unit without a monitor even though they are still at high
risk for developing elevated ICPs and potentially fatal brain herniation. Therefore, there is a clear unmet need
for a non-invasive approach to continuous ICP monitoring.
We propose to develop a non-invasive sensing system to continuously monitor ICP by correlating beat-
to-beat carotid artery BP to ICP.
Prior studies have demonstrated that central aortic waveforms detected at
the extracranial portion of the carotid artery closely resemble ICP waveforms.3-10 In our previous work, we
developed highly sensitivity conformal sensors capable of measuring carotid artery BP waveforms with minimal
applanation pressure.
36,37 W
e have also demonstrated a novel pressure estimation algorithm that can sustain
high accuracy radial artery BP measurements in surgical and ICU patients.
13 By combining our highly sensitive
sensors with our generalizable pressure estimation algorithm,
we hypothesize that we can non-invasively and
continuously monitor ICP by developing a parameter estimation model to correlate our sensor's carotid BP
measurements with ICP waveforms using recordings from Neur

## Key facts

- **NIH application ID:** 11321249
- **Project number:** 5F30HL167584-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** Arash  Abiri
- **Activity code:** F30 (R01, R21, SBIR, etc.)
- **Funding institute:** HL
- **Fiscal year:** 2026
- **Award amount:** $55,114
- **Award type:** 5
- **Project period:** 2023-04-01T00:00:00 → 2027-03-31T00:00:00

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11321249

## Citation

> US National Institutes of Health, RePORTER application 11321249, Non-Invasive Carotid Artery Measurements for Continuous Intracranial Pressure Monitoring (5F30HL167584-04). Retrieved via AI Analytics 2026-09-06 from https://api.ai-analytics.org/grant/nih/11321249. Licensed CC0.

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