# Molecular and Cellular Dynamics in Mammalian Signal Transduction

> **NIH GM R35** · UNIVERSITY OF COLORADO · 2026 · $638,017

## Abstract

PROJECT SUMMARY
This MIRA proposal addresses two important avenues of discovery made by our laboratory. In
Project 1, we will examine a novel mechanism for allosteric regulation of the MAP kinase,
ERK2. This project advances the protein kinase field, by investigating in-depth how protein
motions underlie the activation of ERK and how this affects cellular responses to inhibitors of
this important enzyme. In Project 2, we will investigate a well-known observation that has never
been fully explained, that the responses of cells vary with the strength of ERK signaling. Project
2 advances the signaling field, by discovering and characterizing molecular and cellular events
controlled at different thresholds of ERK activity.

## Key facts

- **NIH application ID:** 11323871
- **Project number:** 5R35GM136392-07
- **Recipient organization:** UNIVERSITY OF COLORADO
- **Principal Investigator:** NATALIE G. AHN
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** GM
- **Fiscal year:** 2026
- **Award amount:** $638,017
- **Award type:** 5
- **Project period:** 2020-04-01T00:00:00 → 2030-02-28T00:00:00

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11323871

## Citation

> US National Institutes of Health, RePORTER application 11323871, Molecular and Cellular Dynamics in Mammalian Signal Transduction (5R35GM136392-07). Retrieved via AI Analytics 2026-07-08 from https://api.ai-analytics.org/grant/nih/11323871. Licensed CC0.

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