PROJECT SUMMARY – CANCER CENTER ADMINISTRATION The Administration of the Wistar Cancer Center unites scientific and administrative priorities in a highly consultative, transparent, and science-focused continuum to achieve programmatic goals. This is aided by the near complete equivalence between Institute and Cancer Center (90% of Wistar faculty are Cancer Center members), a unified leadership structure where an experienced Cancer Center Director is also Institute President and Chief Executive Officer, and a seamless integration of Cancer Center leadership with all institutional decision-making venues. Leveraging a focused and effective set of advisory Cancer Center committees, expansive new leadership and staff appointments, and faculty-driven consultative venues, Cancer Center Administration proactively unites all institutional stakeholders into “ownership” of research goals, incorporates timely feedback on strategic priorities, prioritizes resource allocation, and enables informed and opportunity- driven decision-making. The outcome has been transformative for the Cancer Center. During the last Cancer Center Support Grant (CCSG) budget period, the continuum of Cancer Center Administration coordinated the recruitment of 17 new Cancer Center members at all academic ranks, completed a strategic realignment of Cancer Center Programs with the launch of a new, Genome Regulation and Cell Signaling (GRCS) Program, prioritized an unprecedented, $14.8 million expansion of all eight CCSG-supported Shared Resources, and supported innovative “work-study” programs that transformed the paradigm of workforce development, job creation and public-private partnership in the region. Through a comprehensive and codified process of best practice Cancer Center governance, Administration oversaw the strategic allocation of pilot project funds that enabled new initiatives in population health science and cancer risk, advanced four Wistar discoveries in viral oncogenesis, mitochondria-fue