Project Summary/Abstract This is an application for a 5-year renewal of an institutional training grant in the Epidemiology and Biostatistics of Aging, funded by NIA since 1996. This interdisciplinary program aims to train outstanding predoctoral and postdoctoral candidates to lead the next generation of quantitative research scientists addressing the health of our aging population. It is led jointly by epidemiologists and biostatisticians with a strong commitment to bringing together students in both disciplines to develop expertise in the content areas and methodologies essential to advancing gerontology. Students are trained to conduct leading-edge research that can inform the development of prevention programs to compress morbidity in the aging population. The program is sponsored by the Departments of Epidemiology, Biostatistics, and Mental Health in the Johns Hopkins Bloomberg School of Public Health. It involves faculty from these departments and others in our Schools of Public Health, Medicine, Nursing, and—new to this cycle—Engineering. A Program Director in Biostatistics, Co-Directors from Biostatistics, Epidemiology, and Mental Health, 4 other Associate Directors, and 24 other Core Faculty members will serve as mentors for the trainees. We propose to maintain our current program size of 8 predoctoral / 2 postdoctoral positions, in numbers balanced across our sponsoring departments. We will support postdoctoral fellows at experience level 0, and those with clinical backgrounds seeking advanced research degree training, at level 5. We will target a 3-4 year duration for each predoctoral trainee and a two- year duration for each postdoctoral trainee. A core curriculum is expected of predoctoral trainees and customized to postdoctoral trainees. Trainees will continue to participate in biweekly research in progress meetings, seminars on aging, practica specific to this program, and training to build skills in interdisciplinary collaboration. Didactic and caree