# CEGS: Center for Synthetic Regulatory Genomics - Renewal

> **NIH HG RM1** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2026 · $2,450,000

## Abstract

Title: Center for Synthetic Regulatory Genomics
Abstract
The Center for Synthetic Regulatory Genomics (SyRGe) is tasked with development and
application of revolutionary technology for making dramatic, coordinated changes to
extensive gene loci, which will enable broad investigation of the function of regulatory
sequences and foster translational applications to biotechnology, personalized medicine
and gene therapy. Specifically, we will (i) design and synthesize thousands of >100kbp
constructs probing regulatory function at a carefully selected set of genes; (ii) develop a
pipeline for their single-copy integration at any desired site genome-wide; (iii) survey
libraries for effects on gene expression, chromatin features, and nuclear architecture;
and (iv) develop global computational models to predict regulatory effects of sequence
variation on gene expression. The Center will dramatically supersede present and
predicted technologies for manipulation and assessment of regulatory genome function.
This Center also incorporates a unique and highly successful outreach program whereby
undergraduates play a crucial role in genome assembly, as well as a new Fellows program 
to expose researchers and students from other fields to transformative new technology and 
facilitate its promulgation throughout the larger human genetics and genomics communities.

## Key facts

- **NIH application ID:** 11348852
- **Project number:** 5RM1HG009491-09
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Jef D BOEKE
- **Activity code:** RM1 (R01, R21, SBIR, etc.)
- **Funding institute:** HG
- **Fiscal year:** 2026
- **Award amount:** $2,450,000
- **Award type:** 5
- **Project period:** 2018-06-12T00:00:00 → 2028-02-29T00:00:00

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11348852

## Citation

> US National Institutes of Health, RePORTER application 11348852, CEGS: Center for Synthetic Regulatory Genomics - Renewal (5RM1HG009491-09). Retrieved via AI Analytics 2026-07-25 from https://api.ai-analytics.org/grant/nih/11348852. Licensed CC0.

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