# Deciphering the specificity and molecular mechanisms of regulatory T cells using novel approaches

> **NIH AI DP2** · OHIO STATE UNIVERSITY · 2026 · $450,911

## Abstract

Project Summary: Autoimmunity is a leading cause of chronic illness that encompasses more than 80
individual diseases. Due to the rising prevalence of these diseases, autoimmunity associated health problems
currently affect over 20 million individuals only in the USA, constituting a health crisis that requires immediate
attention. Autoimmune diseases stem from disturbances in the tolerance of immune system against self-tissues.
Immune tolerance is achieved in part by the elimination of self-reactive T cells during their development in the
thymus. The self-reactive clones that escape thymic elimination are actively silenced in the periphery by a
subset of T cells called “regulatory” T (Treg) cells. Because Treg defects result in fatal autoimmunity,
increasing Treg number and activity in the body appears to be a desirable strategy to prevent and treat
autoimmune diseases. However, we have a major gap in our understanding of how Tregs perform their
inhibitory roles at the molecular level and this hinders the development of effective therapeutic strategies.
Recently, I demonstrated, for the first time, that Tregs can inhibit effector T cells in an antigen-specific manner.
I reported that Treg antigen receptor (TCR) can remove class II major histocompatibility complex bound
antigenic peptide (pMHCII) from surface of antigen presenting cell (APC), dendritic cell (DC) in particular, thus
deplete the antigenic stimulus that effector T cell needs to receive to get activated. I revealed that this
happens during Treg-Dendritic cell (DC) contact, whereby cognate pMHCII laden DC membrane is captured
by Treg in an elegant way that does not reduce the presentation of non-cognate pMHCII by the same DC. I
hypothesize that this highly specific mechanism can be exploited to effectively reduce pathological presentation
of self-antigen by APC as a promising strategy to combat autoimmunity. I will test this hypothesis by taking the
following steps: 1) Determining the antigen specificity 

## Key facts

- **NIH application ID:** 11360590
- **Project number:** 5DP2AI154451-05
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** Billur  Akkaya
- **Activity code:** DP2 (R01, R21, SBIR, etc.)
- **Funding institute:** AI
- **Fiscal year:** 2026
- **Award amount:** $450,911
- **Award type:** 5
- **Project period:** 2022-02-19T00:00:00 → 2027-01-31T00:00:00

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11360590

## Citation

> US National Institutes of Health, RePORTER application 11360590, Deciphering the specificity and molecular mechanisms of regulatory T cells using novel approaches (5DP2AI154451-05). Retrieved via AI Analytics 2026-07-03 from https://api.ai-analytics.org/grant/nih/11360590. Licensed CC0.

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