# Signal Transduction to P70 S6 Kinase 1

> **NIH CA R01** · WEILL MEDICAL COLL OF CORNELL UNIV · 2026 · $656,304

## Abstract

Project Summary. (30 lines)
Cancer is the 2nd leading cause of death in the US. The advent of new treatments such as immunotherapy and
targeted therapies have revolutionized the fight against cancer, and when combined with surgery or chemo-
therapy, often result in positive therapeutic responses. Eventually, however, most tumor cells gain the ability to
resist current therapies, making it critical that we continue to define cancer causing and driving processes to
increase the available arsenal of anti-cancer drugs. Given the role of metabolism and metabolic environments
in cancer progression, understanding these aspects of cancer progression also has the potential to reveal new
classes of cancer drugs that take advantage of cancer-associated signaling and metabolic vulnerabilities. mTOR
complex 1 (mTORC1), is a protein kinase complex that senses various environmental cues and coordinates
anabolic and catabolic processes to regulate cellular homeostasis. mTORC1 becomes activated when amino
acids, lipids, energy sources, oxygen and growth factor levels are sufficient. Different cancer cell-associated
mutations provide tumor cells with the ability to optimize usage of these regulatory components or find ways to
overcome deficiencies in these mTORC1 regulators, including nutrients. Additionally, once activated it is still a
mystery how mTORC1 regulates and coordinates the many processes required to promote cell growth,
proliferation, migration, and survival. To better understand mTORC1 signaling, we have combined our mTORC1
phospho-proteome, proteome, interactome, metabolome and gene expression data sets, to support new
discoveries. In this proposal we have outlined several goals based on these data, our recently published work
and the 35 years experience of my lab, that support our long-term goals of defining mTORC1-S6K1 regulation
and signaling, and for revealing new information to support efforts to kill cancer cells with activated mTORC1
signaling. Our discoveries a

## Key facts

- **NIH application ID:** 11370600
- **Project number:** 5R01CA301410-31
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** JOHN  BLENIS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** CA
- **Fiscal year:** 2026
- **Award amount:** $656,304
- **Award type:** 5
- **Project period:** 2025-07-10T00:00:00 → 2030-04-30T00:00:00

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11370600

## Citation

> US National Institutes of Health, RePORTER application 11370600, Signal Transduction to P70 S6 Kinase 1 (5R01CA301410-31). Retrieved via AI Analytics 2026-07-02 from https://api.ai-analytics.org/grant/nih/11370600. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*