PROJECT SUMMARY Multicomponent interventions delivered in school-based health centers (SBHCs) have the potential to decrease asthma morbidity in children from poor neighborhoods. Asthma is the most common chronic disease in children. Children from poor neighborhoods account for a relatively greater percentage of asthma exacerbations, emergency department (ED) visits, and hospitalizations. These children often do not receive guideline-based asthma care, and adherence to daily preventive asthma medication is poor. Traditional health service delivery models where care is received in physicians’ offices have limited success in improving asthma outcomes in children from poor neighborhoods. As a result, these children often receive crisis-driven care rather than prevention-driven care. SBHCs can improve outcomes for children living in poor neighborhoods. SBHCs are staffed by advanced practice providers (APPs) who can assess and manage diseases. There are therefore minimal costs to integrating an asthma management program within this existing health care delivery model. Project ASTHMA (Aligning with Schools To Help Manage Asthma) is a prospective, stepped wedge cluster randomized trial based on a successful pilot study, that aims to assess the effectiveness of SBHCs as a cost effective health care delivery model to reduce asthma symptoms, exacerbations, ED visits, and hospitalizations in children with uncontrolled asthma who live in poor neighborhoods. The intervention will take place in SBHCs located in 10 Buffalo Public Schools. The APPs at the SBHCs randomized to Project ASTHMA that year will be trained and supported to deliver guideline-based chronic asthma care. Students enrolled in Project ASTHMA will receive asthma assessments, spirometry, and preventive medication management from the APPs, directly observed therapy of their preventive asthma medication from school nurses to support adherence, and self- management support to improve adherence to home doses of asthm