# Polygenic Risk Score Methods Development Consortium Coordinating Center

> **NIH HG U01** · UNIVERSITY OF WASHINGTON · 2026 · $544,776

## Abstract

Polygenic Risk Scores (PRS) developed from analysis of large-scale genomic data in epidemiological studies
hold promise as a precision medicine tool that will help identify individuals at higher disease risk. However, a
critical challenge now facing PRS research and clinical translation is that most PRS have been developed
using data from individuals in limited populations, resulting in poorer predictive performance across populations
and reflecting the lack of representation of genetic variation in genomic and biomedical research more broadly.
NHGRI is establishing a new Polygenic Risk Score Methods Development Consortium to address this
challenge by (1) leveraging existing cohorts to improve PRS prediction across populations and for a range of
conditions and (2) optimizing the integration of large-scale genomic and phenotype datasets in support of
collaborative analysis, reporting, and creation of methods and resources for the broader scientific community.
As Coordinating Center, we will support the Consortium's goals by achieving four main aims: (1) leading
harmonization of genotype and phenotype data across Consortium Study Sites and Affiliate Members,
including variant and sample level quality control, genotype imputation, and use of standard phenotype
ontologies. (2) Organizing cross-Consortium analysis and collaborative methods development, featuring
standardized evaluation of PRS methods to identify consensus approaches, development of a local-ancestry
informed PRS method, and integration of ELSI considerations into analytic best-practices. (3) Facilitating data
sharing within and beyond the Consortium through community resources and repositories such as the NHGRI
Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL), NCBI database of
Genotypes and Phenotypes (dbGaP), and the Polygenic Score Catalog. (4) Coordinating program logistics and
outreach including through a Consortium website, in-person meetings, mentorship and training, a

## Key facts

- **NIH application ID:** 11483219
- **Project number:** 3U01HG011697-05S1
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Kenneth M. Rice
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** HG
- **Fiscal year:** 2026
- **Award amount:** $544,776
- **Award type:** 3
- **Project period:** 2026-04-01T00:00:00 → 2027-03-31T00:00:00

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11483219

## Citation

> US National Institutes of Health, RePORTER application 11483219, Polygenic Risk Score Methods Development Consortium Coordinating Center (3U01HG011697-05S1). Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/grant/nih/11483219. Licensed CC0.

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