# eMERGE IV Northwest: A partnership to evaluate the use of genomic information in the health care of diverse participants

> **NIH HG U01** · UNIVERSITY OF WASHINGTON · 2026 · $828,982

## Abstract

Project Abstract
This eMERGE IV (E4) supplement proposes extend the outcomes timeline for the prior implementation of 10
“genomic risk assessment” (GIRA) scores in a network-wide set of participants. These GIRAs include
polygenic risk score (PRS) information, as well as risk information, such as personal and family health history,
environmental and social health determinants, and physical and lab measures. Substantial challenges must be
addressed before genomic medicine is a part of standard medical care. The specific aims of our proposal are
designed to use an implementation science approach to advance the integration of genomic data into clinical
practice, including evaluation of patient perspectives and economic outcomes, and broadening the impact of
eMERGE through collaborations. The University of Washington Medicine dedication to preventative health in a
learning health system and broad expertise across genomics, statistical, ethical, informatic, implementation,
outcomes and economic disciplines will support this multi-site clinical trial. We will continue our leadership in
data-cleaning and in the analyses of 6 and 12 month post-return outcomes data.

## Key facts

- **NIH application ID:** 11506039
- **Project number:** 3U01HG008657-10S2
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** David Russell Crosslin; Gail Pairitz Jarvik
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** HG
- **Fiscal year:** 2026
- **Award amount:** $828,982
- **Award type:** 3
- **Project period:** 2026-03-01T00:00:00 → 2027-04-30T00:00:00

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11506039

## Citation

> US National Institutes of Health, RePORTER application 11506039, eMERGE IV Northwest: A partnership to evaluate the use of genomic information in the health care of diverse participants (3U01HG008657-10S2). Retrieved via AI Analytics 2026-06-29 from https://api.ai-analytics.org/grant/nih/11506039. Licensed CC0.

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