The Informatics, Decision-Enhancement, and Analytic Sciences (IDEAS) Center of Innovation creates a dynamic environment within the Veterans Health Administration (VHA) where informatics is tightly integrated with health services research and other disciplines. Biomedical informatics is a unifying theme of the IDEAS Center, as many of our investigators are both health services researchers and informaticians, engaging in research that bridges both fields. This overlap reflects the historical prominence of informatics at the VA Salt Lake City Health Care System and our close affiliation with VA Informatics and Computing Infrastructure (VINCI).The IDEAS Center seeks to drive transformation of healthcare delivery in the Veterans Health Administration through an integrated portfolio of translational research closely tied to operational partnerships: • Apply qualitative and quantitative methods of inquiry to elicit stakeholder perspectives, characterize clinical gaps, and identify information needs. • Generate new knowledge to improve prediction of impacts of health system changes, to support clinical practice improvement, and to guide mitigation of adverse outcomes in Veterans. • Design and implement innovative solutions to high priority problems, advancing VHA as a learning health care system. • Collaborate with operational partners to disseminate interventions that enhance the quality, efficiency, and safety of health care delivery in the Veterans Health Administration and improve Veteran health. IDEAS includes two areas of focused research, one emerging research area, and five methodological cores. Our research reflects our investigators’ clinical expertise, coupled with our methodological strengths in information visualization, natural language processing, decision-support system design, population analytics, qualitative research, and pharmacoepidemiology. Our methods cores highlight our expanded research activities, recruitment of new investigators, and increased emphasis on implementation science. Focus Area 1, Combating Antibiotic Resistance, integrates our original focus areas, cognitive support for therapeutic decision-making and healthcare-associated infections, and links with our new VA Quality Enhancement Research Initiative (QUERI) Program, Combatting Antimicrobial Resistance through Rapid Implementation of Available Guidelines and Evidence (CARRIAGE), to implement research innovations into the field. Our vision is of a transformed VHA, recognized for its national leadership and success in antibiotic stewardship and infection prevention. Focus Area 2, Mitigating Health Risks in Veterans across Periods of Vulnerability, extends our Center’s previous research on post-deployment and rural health, integrating the expertise of our recently recruited junior and senior investigators in addiction medicine, traumatic brain injury, and mental health. We will leverage new types of data and state-of-the-art analytical approaches to better characte...