# Highly sensitive measurement of cTnI without a reader: the Xip solution

> **NIH NIH R44** · SILICON BIODEVICES, INC. · 2020 · $565,200

## Abstract

Project Summary
Acute myocardial infarction (MI) is the biggest killer in the western world and is the cause of
death for nearly 500,000 Americans each year. The symptoms of MI can be vague and non-
specific and 7 million adults present to hospital Emergency Departments in the US each year
with suspected MI. Advances in cardiac biomarkers have had a large impact on the diagnosis,
risk stratification and management of suspected MI patients and rapid and sensitive testing of
cardiac biomarkers, specifically troponin, has become the cornerstone for diagnostic workup
and care of suspected MI patients. Rapid troponin testing can decrease time to appropriate
treatment for MI patients and allow for faster MI rule-out, which will help decrease the billions
expended annually for the care of non-MI patients in coronary care units. Yet, despite the clear
need for sensitive and rapid cardiac troponin measurements to quickly diagnose and manage
patients, there is no POC system that can match the analytical performance of contemporary
sensitive laboratory systems. This project is intended to develop and commercialize a fully
integrated POC immunoassay platform, based on a CMOS microchip, that is as easy to use as
an over the counter pregnancy test and as accurate as high sensitivity laboratory tests. In
addition to troponin, which is critically important, the system will be able to measure a myriad of
other biomarkers for heart failure, pulmonary embolism and deep vein thrombosis, sepsis and
other conditions where speed, convenience and in the field measurement of biomarkers is
important.

## Key facts

- **NIH application ID:** 9674520
- **Project number:** 5R44HL116078-05
- **Recipient organization:** SILICON BIODEVICES, INC.
- **Principal Investigator:** Rajinder Bhatia
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $565,200
- **Award type:** 5
- **Project period:** 2012-08-15 → 2021-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9674520

## Citation

> US National Institutes of Health, RePORTER application 9674520, Highly sensitive measurement of cTnI without a reader: the Xip solution (5R44HL116078-05). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/9674520. Licensed CC0.

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