The VA RR&D Center for Neurorestoration and Neurotechnology (CfNN) at the Providence VA Medical Center (PVAMC) unifies a distinguished team of scientists, engineers and clinicians from the VA, Brown University, and affiliated hospitals to develop and translate neurotechnologies and device-based therapies that restore function for Veterans with disorders affecting the nervous system. CfNN’s three Focus Areas are each dedicated to performing the rigorous, peer-reviewed science that leads to new diagnostic and therapeutic strategies for Veterans with spinal cord injury, stroke, amyotrophic lateral sclerosis (ALS), epilepsy, limb loss, post-traumatic stress disorder (PTSD), depression, chronic pain, and other nervous system diseases or injuries. CfNN’s three Focus Areas are: (1) Restoring Communication and Mobility (2) Restoring Affective and Cognitive Health, and (3) Restoring Limb Function. The Focus Areas’ interdisciplinary research efforts are supported by three Cores providing essential infrastructure support and specialized services: (A) Neuromodulation and Neuroimaging (B) Recording, Decoding, and Computational Neuroscience, and (C) Assessment, Outcome Measurement, and Implementation. CfNN research is further facilitated by a dedicated administrative staff who support scientific productivity, coordinate the synergistic relationships between CfNN and its academic and clinical affiliates, maintain close contact with local and national VA officials, and optimize our service to Veterans. CfNN’s research strategy maximizes interactions via complementary expertise and resources among its Focus Areas and Cores. This in turn supports a high- impact research community focused on application of medical devices to neurologic health, both within the VA and in the wider regional and national brain science community. Through this renewal, over the next five years CfNN will leverage and expand its collaborative research, both within the Providence VAMC and together with other VA Centers, toward rehabilitation goals important to the large number of affected Veterans and their families. These include: restoring arm and leg movement for Veterans with stroke, spinal cord injury, or amputation;; improving communication for Veterans with ALS;; improving the understanding, early detection, and management of seizures, and;; more successfully treating Veterans with PTSD, depression, obsessive-compulsive disorder, or other severe cognitive or affective disorders. CfNN also aims to develop and validate the outcomes measures needed for effective clinical trials of new restorative neurotechnologies for these conditions. In addition to the research of its core investigators, CfNN is designed to facilitate the training and research careers of junior researchers and to recruit established clinicians and scientists to focus their research efforts on improving rehabilitation for Veterans with nervous system disease or injury. CfNN is committed ...