# Resolution of Neuroinflammation and Persistent Pain by Complementary Approaches

> **NIH NIH P01** · DUKE UNIVERSITY · 2020 · $1,699,677

## Abstract

The goal of this program project is to establish a NCCIH Center of Excellence is to investigate neuroinflammatory
mechanisms underlying multiple complementary and integrative health (CIH) approaches, including
electroacupuncture and natural product docosahexaenoic acids. The overarching hypothesis for the entire P01
is that different CIH approaches may modify distinct inflammatory and neuroinflammatory profiles to achieve
their therapeutic potentials in pain management. This hypothesis will be tested in 4 projects using four animal
models relevant to different types of clinical pain conditions, in combination with sex and stress. In response to
rising opioid crisis in the US, this PPG will conduct cutting-edge basic science research and pave the road for
future clinical trial at the center for rapid translation of the identified complementary approaches that can
effectively modulate neuroinflammation.

## Key facts

- **NIH application ID:** 9703529
- **Project number:** 1P01AT009968-01A1
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Joseph P Mathew
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,699,677
- **Award type:** 1
- **Project period:** 2020-04-20 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9703529

## Citation

> US National Institutes of Health, RePORTER application 9703529, Resolution of Neuroinflammation and Persistent Pain by Complementary Approaches (1P01AT009968-01A1). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/9703529. Licensed CC0.

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