# Chicago Stroke Trials Consortium

> **NIH NIH U24** · UNIVERSITY OF CHICAGO · 2020 · $314,802

## Abstract

Stroke is a leading cause of death and disability in the United States. Despite scientific and technological
advances, there has been limited translation into clinical outcome benefits for stroke patients. Since 2013, a
cohesive and integrated Stroke Trials Network has been working to develop breakthrough stroke treatments
with an emphasis on rapid execution of clinical trials with sufficient sample sizes, robust enrollment, timely
completion, and rigorous and uniform infrastructure across sites.
 This application is in response to the recent NINDS request for Regional Coordinating Stroke Centers
(RCC) in the NINDS Stroke Trials Network (PAR-17-276). The Chicago Stroke Trials Consortium (CSTC) led
by the RCC at Northwestern University (NU) has been an integral part of the NIH StrokeNet. In this renewal
application, we expand our network to include 12 centers in the Chicago and Milwaukee metropolitan areas:
Northwestern Memorial Hospital, Lurie Children's Hospital, Shirley Ryan Ability Lab, (all part of NU's McGaw
Medical Center), the University of Chicago, Rush University Medical Center, Loyola University Chicago,
University of Illinois at Chicago, Medical College of Wisconsin, the Hektoen Institute for Medical
Research/John H. Stroger, Jr. Hospital of Cook County, Central Dupage Hospital, Northwest Community
Hospital, and Edward Hines, Jr. VA Hospital. We have enlisted institutional support including agreements to
utilize a federated institutional review board process (central IRB) and master trial agreements to ensure rapid
implementation of future trials from each of our participating sites. The RCC aims to combine resources,
diverse faculty with stroke expertise, and access to a multi-ethnic population of stroke patients spanning from
children to elderly and from acute treatment to rehabilitation. The CSTC will participate in acute stroke,
rehabilitation, and prevention trials, and has expertise from investigators in vascular neurology, neurosurgery,
neurocritical care, neuroradiology, interventional neuroradiology, neurorehabilitation, pediatric neurology, and
emergency medicine. The amassed investigators have backgrounds in all aspects of stroke research and
leadership roles in many recently completed and ongoing NIH and industry-sponsored trials. The consortium
has a combined geographic referral base encompassing almost 10 million people and has a history of
collaboration in clinical and scientific endeavors. Drawing from the vast geographic reach of our hospitals,
their resources and investigators, and substantial contributions to StrokeNet during the initial award period,
the CSTC is uniquely qualified to continue to deliver a diverse stroke patient population, provide consolidated
multi-disciplinary and multi-institutional expertise and leadership for StrokeNet trials, and ensure mentoring for
trainees and junior faculty seeking academic careers in stroke.

## Key facts

- **NIH application ID:** 9756475
- **Project number:** 5U24NS107233-03
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** Shyam Prabhakaran
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $314,802
- **Award type:** 5
- **Project period:** 2018-08-15 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9756475

## Citation

> US National Institutes of Health, RePORTER application 9756475, Chicago Stroke Trials Consortium (5U24NS107233-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9756475. Licensed CC0.

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