Project Summary/Abstract Prader-Willi Syndrome (PWS) has been designated as a rare disease by the National Institutes of Health and is categorized as such with the NIH Office of Rare Diseases Research. [1]. Inclusion on this list requires a prevalence of less than 200,000 people in the United States. According to the Prader-Willi Syndrome Association USA and a review of the literature, current estimates of the prevalence of PWS range from 1: 8,000 – 1: 30,000 with the most likely prevalence falling around 1 : 15,000 individuals [2-8]. Based on current U.S. Census data there are 317,434,622 people living in the U.S. Using the above prevalence estimates, the prevalence of PWS ranges from 10,581 to 39,679, and the most likely prevalence is approximately 21,000 Americans [9]. Using the most current available data from the U.S. Census (2010), there are 74,181,467 people in the pediatric population in the US (age < 18 years) [10]. Assuming that the prevalence of PWS falls between 1: 8,000 and 1: 30,000, there are currently between 2,473 and 9,273 people under age 18 with PWS. PWS is a rare neurodevelopmental disorder caused by lack of expression of paternally derived imprinted material on chromosome 15q11-q13. PWS is characterized by mild to moderate intellectual disabilities, repetitive/ compulsive behaviors and rigidity, social cognition deficits and severe hypotonia at birth, followed by the onset of hyperphagia later in life. Obesity is responsible for the majority of the morbidity and mortality associated with PWS, and compulsive eating behaviors are most responsible for diminishing the quality of life for caregivers and family members. Oxytocin has been implicated in the pathophysiology of PWS and there have been small studies of intranasal oxytocin (IN-OXT) in this population. To date, however, studies have not been adequately powered to detect significance in target symptoms of hyperphagia and associated symptoms of individuals with PWS. The overall goal of this proposal is to study the safety and efficacy of IN-OXT on hyperphagia as measured by the Revised Dykens Hyperphagia Questionnaire from baseline to week 8. Currently, there are no effective treatments available to manage hyperphagia in patients with PWS. Objective: The overall objective of this Phase 2 trial is to compare the change from baseline to week 8 of the peptide IN-OXT on changes on the Revised Dykens Hyperphagia Questionnaire in children with PWS. We have obtained an IND for the use of IN-OXT for PWS (IND 121109). We have acquired the IN-OXT and matching placebo (Manufactured by Novartis as Syntocinon - see letter and COA in appendix). This Phase 2 study is designed to generate preliminary data for future Phase 3 trials, and targets symptoms in this population that currently have no effective treatments. By treating these symptoms earlier in life in a pediatric PWS population, we may maximize the treatment impact. This study supports the Orphan Product Divisions goal of identif...