# Clinical analysis of Trem-Like Transcript-1 in large cohorts of patients from the NHLBI Biorepository

> **NIH NIH R21** · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · 2020 · $22,380

## Abstract

ABSTRACT:
Triggering receptor expressed in Myeloid cells (TREM) Like transcript (TLT)-1 is a prominent
platelet receptor stored in the -granules of platelets. While it is virtually absent on the surface
resting platelets, it highly expressed on the surface of activated platelets and released as a soluble
fragment (sTLT-1). TLT-1 binds to neutrophils and endothelial cells. During acute inflammation it
mediates smooth leukocyte transmigration out of the vessels protecting the vessels from
excessive bleeding. The effect is particularly prominent in the lungs. TLT-1 interaction with
endothelial cells initiates cell growth and proliferation and when targeted in a Lewis lung
carcinoma model displays anti-angiogenic properties. As such our studies have defined roles for
TLT-1 in acute lung inflammation, atherosclerosis, and cancer. Here we propose to clinically
translate our findings using the rich resource presented by the NIH biorepository. We will
investigate samples from ARDS patients to find clinical correlation of TLT-1 positive microparticles
with the mortality and hospital stay. We will evaluate samples from cardiovascular patients in the
PEACE study for correlations of the soluble fragment and TLT-1 positive microparticles with
adverse cardiac events..

## Key facts

- **NIH application ID:** 9781760
- **Project number:** 5R21HL140268-02
- **Recipient organization:** UNIVERSITY OF PUERTO RICO RIO PIEDRAS
- **Principal Investigator:** A. Valance Washington
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $22,380
- **Award type:** 5
- **Project period:** 2018-09-10 → 2021-02-01

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9781760

## Citation

> US National Institutes of Health, RePORTER application 9781760, Clinical analysis of Trem-Like Transcript-1 in large cohorts of patients from the NHLBI Biorepository (5R21HL140268-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9781760. Licensed CC0.

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