# Anxiety, IL-1R1 and neuroinflammation

> **NIH NIH R01** · FLORIDA ATLANTIC UNIVERSITY · 2020 · $373,750

## Abstract

   
DESCRIPTION (provided by applicant): Increasing evidence points to inflammation as contributing factor for the pathogenesis of psychopathologies, including depression and anxiety. Work from our collaborative group has established that the inflammatory cytokine interleukin-1 (IL-1) is a crucial mediator of stress induced anxiety. The pathways by which IL-1 induces inflammatory anxiogenesis, however, remain unknown. In this R01 application, we will investigate the novel hypothesis that IL-1 acts on brain endothelial cells to trigger inflammatory microglial activation, which is required for the induction of anxiety behaviors. We will use our newly created IL-1R1 restore mouse lines to study cell type specific IL-1R1 mediated microglial activation and isolate the pathogenic pathways by which IL-1 contributes to anxiogenesis.

## Key facts

- **NIH application ID:** 9814000
- **Project number:** 5R01MH109165-06
- **Recipient organization:** FLORIDA ATLANTIC UNIVERSITY
- **Principal Investigator:** Ning Quan
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $373,750
- **Award type:** 5
- **Project period:** 2016-02-10 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9814000

## Citation

> US National Institutes of Health, RePORTER application 9814000, Anxiety, IL-1R1 and neuroinflammation (5R01MH109165-06). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9814000. Licensed CC0.

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