# Mechanistic-based biomarkers of abusive alcohol consumption

> **NIH VA I01** · RLR VA MEDICAL CENTER · 2020 · —

## Abstract

Project Summary
Excessive alcohol use (EAU) is becoming recognized as an emerging health-related problem especially
among veterans returning from combats. There is a need for increased vigilance and action to identify
and counsel these at-risk veterans. Unfortunately, we lack the reliable diagnostic tests to detect the
dangerous levels of drinking. Such tests would be indispensable for screening and care for veterans
with excessive alcohol use. We hypothesize that several novel serum and urine markers based on the
effect of alcohol on immune cells can be used as the predictive biomarkers for EAU. To test this
hypothesis, we plan to pursue the following specific aims. SPECIFIC AIM # 1. To determine the effect
of EAU on organ systems using system biology and by detecting, identifying, and comparing the
relative quantity of these novel targets and evaluate these as potential biomarkers and SPECIFIC AIM
# 2. To determine the predictive capacity of these biomarkers for alcohol-related health consequences.
If successful, the results from this project will revolutionize the screening methods for veterans with
excessive alcohol use.

## Key facts

- **NIH application ID:** 9814094
- **Project number:** 5I01CX000361-07
- **Recipient organization:** RLR VA MEDICAL CENTER
- **Principal Investigator:** Suthat Liangpunsakul
- **Activity code:** I01 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2020
- **Award amount:** —
- **Award type:** 5
- **Project period:** 2011-10-01 → 2021-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9814094

## Citation

> US National Institutes of Health, RePORTER application 9814094, Mechanistic-based biomarkers of abusive alcohol consumption (5I01CX000361-07). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9814094. Licensed CC0.

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