Project Summary/Abstract (1) Our work is directed towards understanding the structure, organization, and anatomy of human memory. We study neurological patients who have circumscribed memory impairment as the result of brain injury or disease that has damaged the hippocampus bilaterally. We also study healthy volunteers using the technique of functional magnetic resonance imaging (fMRI). This work is continuing to reveal useful and important information about the organization of memory and the brain systems that support memory. In this work, I collaborate with Christine Smith, Ph.D. at the VA (Research Health Science Specialist), who in 2016 obtained independent VA funding. I also collaborate with Robert Clark, Ph.D. (VA investigator) in his program of work on memory in rodents. Memory is a precious mental faculty. Lost or diminished memory, as occurs in neurological disease, leads to a loss of self, a loss of one’s life history, and a loss of the ability to have enduring contact with other human beings. Memory problems are common in VA neurological and psychiatric patients. Modest difficulties with memory are of course well-documented as a universal feature of normal aging, and more severe memory problems are a prominent early sign of Alzheimer’s disease. Our work is intended to learn how memory is affected by these conditions, how the brain accomplishes learning and memory, and what brain structures are important. Our neuropsychological work has provided new tests, the possibility of better and earlier diagnosis, improved understanding of the conditions that affect memory, and established a clearer path to the development of interventions for treating and ultimately preventing diseases that affect memory. During the past 10 years, our work has been reported in 95 publications, (53 peer-reviewed journal articles, 20 books or book chapters, 18 invited reviews, and four other pieces). We explored a number of issues that are prominent in current discussions about the organization of memory. We investigated how eye movements can be experience-dependent (e.g., different depending on whether a scene is novel or recently presented); the key distinction between conscious and unconscious memory systems; the function of the hippocampus with respect to the constructs of recollection and familiarity; the brain-based distinction between short-term (working) memory and long-term memory; the role of the hippocampus and related medial temporal lobe structures in recollecting the recent past, the remote past, and in imagining the future; the special status of face recognition with respect to hippocampal function; the possible role of medial temporal lobe structures in certain perceptual functions; and the role of these structures in navigation, scene construction, and spatial cognition. Over my career, my work has been cited 48,000 times and continues to be cited about 2000 times/year. My h-index is 108. Current work proceeds on several fronts. First, we are...