# Surgical Trauma-Induced Vascular Injury

> **NIH VA I01** · VETERANS HEALTH ADMINISTRATION · 2020 · —

## Abstract

Surgical trauma occurs to blood vessels such as the human saphenous vein (HSV)
when it is harvested from the lower extremity and transplanted into the arterial
circulation as an arterial bypass graft. This project will determine the molecular
mediators that lead to decreased function of HSV and blood vessels after surgical
injury. Since “the response to injury” has been implicated in modulating vein graft
failure, a better understanding of the molecular mechanisms of surgical trauma would
decrease myocardial infarction, re-do operations and limb loss associated with vein
graft failure. This work will also provide new insights in pathologic surgical injury with
potential extensions to other applications such as vascular injury during angioplasty,
transplantation, and trauma.

## Key facts

- **NIH application ID:** 9815449
- **Project number:** 5I01BX003882-03
- **Recipient organization:** VETERANS HEALTH ADMINISTRATION
- **Principal Investigator:** Colleen M Brophy
- **Activity code:** I01 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2020
- **Award amount:** —
- **Award type:** 5
- **Project period:** 2017-10-01 → 2019-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9815449

## Citation

> US National Institutes of Health, RePORTER application 9815449, Surgical Trauma-Induced Vascular Injury (5I01BX003882-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9815449. Licensed CC0.

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