# The Role of Stress-Immune-Connectome Disruption in Mechanisms of Chinese Early Schizophrenia Spectrum

> **NIH NIH R01** · UNIVERSITY OF MARYLAND BALTIMORE · 2020 · $199,999

## Abstract

Project Summary / Abstract
The advent of non-invasive connectivity-oriented neuroimaging methods has shed new light onto the inner
workings of the brain. The brain's functional and structural connectome play key roles in regulating the
pathways from genes to neural systems to mental illnesses. Along these pathways, we hypothesize that
abnormal activity in the innate stress-immune pathways has a major contribution to the brain connectome
disruption in early stage of schizophrenia spectrum disorder and to its clinical consequence. The project
proposes to extend the Connectome Project in Mental Illness to characterize brain circuitry and its relation to
stress-immune axis dysfunction in early stage of schizophrenia spectrum disorder in China. We propose a
longitudinal study in a large sample of patients that aims to overcome the heterogeneity in the relationship
between mental illness and stress-immune-connectome axis, a well-recognized barrier to advancing research
and treatment. We will recruit 500 patients with schizophrenia spectrum disorders within five years of disease
onset. They will be assessed using modern chronic stress and acute psychological stress laboratory paradigms
to define the stress biomarkers at baseline. The patients will be compared with 250 age and sex matched
healthy controls. The collaboration leverages the clinical stress research expertise by the U.S. partner and the
the clinical immunology research expertise in schizophrenia by the Chinese partner. The proposed study also
builds on our ongoing work using acute and chronic stress paradigms to understand how stress is linked to
brain structural and functional connectome in schizophrenia spectrum disorders. This novel proposition in U.S.
and Chinese mental health research field is strongly supported by preliminary data. The ability to apply the
cutting edge connectome protocol using the advanced research designated scanner in Beijing will also
enhance our ability to use multimodal imaging tools to aid biologically based heterogeneity reduction. Together,
this study will generate actionable strategies to treat and prevent brain connectome deterioration and facilitate
clinical recovery after psychosis onset.

## Key facts

- **NIH application ID:** 9820733
- **Project number:** 5R01MH112180-04
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** L Elliot Elliot Hong
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $199,999
- **Award type:** 5
- **Project period:** 2017-02-01 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9820733

## Citation

> US National Institutes of Health, RePORTER application 9820733, The Role of Stress-Immune-Connectome Disruption in Mechanisms of Chinese Early Schizophrenia Spectrum (5R01MH112180-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9820733. Licensed CC0.

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