# Role of proteasome activity in adaptive immunity

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $444,435

## Abstract

Project Summary
 Mortality from infectious diseases remains a leading cause of death worldwide,
making the development of new vaccines an important priority of biomedical research.
Immunologic memory is a cardinal feature of adaptive immunity and an important goal of
vaccination strategies. Traditional vaccination strategies are very effective at generating
neutralizing antibodies against bacteria and viruses. However, a vaccine capable of
generating robust T lymphocyte memory is still beyond our research, due, in part, to an
incomplete understanding of how lymphocyte fates are specified. In this grant
application, we propose to study the role of proteasome degradation activity in
controlling this process.

## Key facts

- **NIH application ID:** 9822955
- **Project number:** 5R01AI129973-03
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** John T Chang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $444,435
- **Award type:** 5
- **Project period:** 2017-12-01 → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9822955

## Citation

> US National Institutes of Health, RePORTER application 9822955, Role of proteasome activity in adaptive immunity (5R01AI129973-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9822955. Licensed CC0.

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