# Targeting fascin to block tumor metastasis

> **NIH NIH R01** · WEILL MEDICAL COLL OF CORNELL UNIV · 2020 · $386,236

## Abstract

   
DESCRIPTION (provided by applicant): Tumor metastasis is the major cause of death in cancer patients. Thus, blocking tumor metastasis will significantly increase the survival rate of cancer patients and allow more moderate radiation or chemotherapy with less side-effects. One critical step of tumor metastasis is tumor cell migration and invasion. In this application, we focus on fascin, an actin-bundling protein, which is critical for tumor invasion and metastasis. Elevated expression of fascin is correlated with poor prognosis and short survival in cancer patients. In specific aim 1, we will investigate the mechanism of action of fascin inhibitors. In specific aim 2, we will further optimize fascin inhibitors. In specific aim 3, we will use animal models to examine the efficacy and toxicity of optimized fascin inhibitors.

## Key facts

- **NIH application ID:** 9829492
- **Project number:** 5R01CA193815-05
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** Xin-Yun Huang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $386,236
- **Award type:** 5
- **Project period:** 2015-12-08 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9829492

## Citation

> US National Institutes of Health, RePORTER application 9829492, Targeting fascin to block tumor metastasis (5R01CA193815-05). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/9829492. Licensed CC0.

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