Role of Piezo2 and Nav channels in rapidly-adapting neuronal mechanoreceptors

NIH RePORTER · NIH · R01 · $366,406 · view on reporter.nih.gov ↗

Abstract

Of all the sensory modalities possessed by vertebrates, the ability to sense mechanical force remains the least well understood at the cellular and molecular level. In the glabrous skin, touch is sensed by Meissner and Pacinian corpuscles – the detectors of fine objects and minute skin deformations. The corpuscles are innervated by rapidly-adapting neuronal mechanoreceptors, which can directly convert touch into excitation, by an unknown mechanism. Here, we aim to elucidate this mechanism by studying the mechanosensitivity in rapidly-adapting mechanoreceptors, using the trigeminal system of the duck embryo as a model. Duck trigeminal ganglia contain a large proportion of rapidly-adapting mechanoreceptors, which innervate the numerous Meissner- and Pacinian-like corpuscles in the glabrous skin of the bill. Using this model, we aim to determine the role of stretch-sensitive cationic and voltage-sensitive sodium channels in the three principal processes of touch sensitivity: (1) the conversion of touch into excitatory current; (2) the generation of action potential, and (3) propagation of the rapidly-adapting afferent message along the axon. Our studies will reveal cellular and molecular principles underlying the sense of touch in rapidly-adapting neuronal mechanoreceptors.

Key facts

NIH application ID
9830091
Project number
5R01NS097547-04
Recipient
YALE UNIVERSITY
Principal Investigator
Sviatoslav Bagriantsev
Activity code
R01
Funding institute
NIH
Fiscal year
2020
Award amount
$366,406
Award type
5
Project period
2016-12-01 → 2021-11-30