# In vivo assessment of meningeal inflammation and its clinical impact in multiple sclerosis by 7 Tesla MRI

> **NIH NIH R01** · UNIVERSITY OF MARYLAND BALTIMORE · 2020 · $609,639

## Abstract

Although MRI is the major diagnostic and prognostic tool used in the care of patients with multiple
sclerosis (MS), many aspects of MS pathology are still not well visualized. Recent histopathologic studies in
MS have shed light on a previously unrecognized phenomenon without a proven MRI correlate- meningeal
inflammation. Pathologic data suggests that meningeal inflammation in MS is not a bystander phenomenon,
with strong links found between meningeal inflammation and pathologic findings of cortical pathology and
neurodegeneration and a clinical phenotype characterized by rapid disability accumulation, progressive
subtypes, and an earlier time to death.
 To date, explorations of the role of meningeal inflammation in MS have been primarily limited to autopsy
studies. In this application, we propose to use gadolinium-enhanced 7 Tesla (7T) MPFLAIR MRI as a non-
invasive biomarker of meningeal inflammation in MS. Our preliminary data utilizing this approach demonstrates
leptomeningeal contrast enhancement, which we propose as a marker of meningeal inflammation, in 76% of
participants with MS. We will use this tool to investigate a hypothesis that meningeal inflammation in MS
may be more ubiquitous than previously thought, is not effectively targeted by current treatments, and
is related to some of the more damaging and poorly addressed aspects of MS (cortical injury, cognitive
deficits, fatigue, and progressive disability accumulation). Participants with MS will undergo annual study
visits including a 7T MRI of the brain, physical and cognitive disability assessments, and optical coherence
tomography (OCT), in addition to a one-time lumbar puncture.
 The choice of leptomeningeal enhancement on 7T MPFLAIR MRI as an in vivo biomarker of meningeal
inflammation will be justified through comparisons to other MRI sequences and other field strengths in addition
to demonstration of a link between leptomeningeal enhancement and spinal fluid markers of meningeal
inflammation through cytokine profiling and flow cytometry. We will also use this imaging tool to demonstrate
an association between meningeal inflammation and a more disabling MS phenotype through clinical data, in
addition to cognitive and physical disability scales. Finally, we will use this imaging tool to demonstrate an
association between meningeal inflammation and cortical pathology (cortical lesions and cortical relaxometry
alterations on 7T MRI) and neurodegeneration (retinal nerve fiber layer thinning on OCT).
 Validation of neuroimaging methods for in vivo quantification of meningeal pathology and confirmation
of its clinical relevance has the potential to change the treatment landscape in MS. The tools developed in this
study would find future use as non-invasive surrogate outcome measures in clinical trials of drugs designed to
reduce meningeal inflammation and its impact, in addition to acting as a means to select patients in whom
such treatments would be justified and to monitor treatme...

## Key facts

- **NIH application ID:** 9830700
- **Project number:** 5R01NS104403-03
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** Daniel M Harrison
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $609,639
- **Award type:** 5
- **Project period:** 2018-02-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9830700

## Citation

> US National Institutes of Health, RePORTER application 9830700, In vivo assessment of meningeal inflammation and its clinical impact in multiple sclerosis by 7 Tesla MRI (5R01NS104403-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9830700. Licensed CC0.

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