# Analytical Neurochemistry: Core D

> **NIH NIH U54** · CHILDREN'S HOSP OF PHILADELPHIA · 2020 · $215,942

## Abstract

(ANALYTICAL NEUROCHEMISTRY CORE (ANC): CORE D) 
PROJECT SUMMARY
Description: The Analytical Neurochemistry Core (ANC) supports these services: (a) Quantitation of amino
acids and biogenic amines; (b) Kinetic studies of flux through metabolic pathways using stable isotopes as
tracers and mass spectrometry to measure isotopic enrichment; (c) Qualitative and quantitative mass
spectroscopic analyses of proteins/peptides and their modifications; and (d) Bioenergetic assays of
mitochondrial function. Analyses are performed: (a) In vitro; (b) In pre-clinical animal models of intellectual and
developmental disabilities (IDD); and (c) In vivo, in human patients. Users have access to a broad repertoire of
analytical services, as well as expert advice with regard to experimental design and data interpretation. The
core emphasizes all aspects of quality control, including assurance that studies are adequately powered and
properly controlled. When feasible, analyses are performed in a blinded fashion.
Relevance to IDDRC Mission: The overall theme of our Center is – “Genes, Brain and Behavior”. The primary
focus of the ANC is “Brain”, or the neurochemical changes which result from gene mutation and variation.
These neurochemical aberrations may contribute to the behavioral anomalies that become clinical
manifestations of IDD. The ANC enables users to identify and quantify changes in brain biochemistry. Such
information deepens understanding of the IDD and affords development of biomarkers with which to gauge the
efficacy of therapeutic interventions.
Eligibility: These services are available both to approved users of the IDDRC at CHOP/UPenn and to users at
other Centers in the Network.

## Key facts

- **NIH application ID:** 9831583
- **Project number:** 5U54HD086984-05
- **Recipient organization:** CHILDREN'S HOSP OF PHILADELPHIA
- **Principal Investigator:** Michael Byrne Robinson
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $215,942
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9831583

## Citation

> US National Institutes of Health, RePORTER application 9831583, Analytical Neurochemistry: Core D (5U54HD086984-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9831583. Licensed CC0.

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