# Preclinical Models: Core F

> **NIH NIH U54** · CHILDREN'S HOSP OF PHILADELPHIA · 2020 · $152,876

## Abstract

(PRECLINICAL MODELS CORE (PMC): CORE F) 
PROJECT SUMMARY
Description: The Preclinical Models Core (PMC) supports IDDRC users who seek new treatments for IDD by
studying these disorders in 3 kinds of preclinical models: (1) Rodent models: This Core component
characterizes behaviors in mouse models of genetic or acquired disabilities. Measured behaviors include
learning, memory, social preference, ultrasonic vocalization, sleep and anxiety. (2) Stem cell models: This
Core component assists users to create disease models by generating induced pluripotent stem cells (iPSCs)
using standard reprogramming technologies or by genome editing, such as CRISPR-Cas, on established iPSC
lines. These cells, some derived from humans with IDD, afford a model in which to scrutinize cellular
consequences of genetic disease and to evaluate the efficacy of possible therapies. (3) Tissue culture models:
This Core component supports users to generate tissue culture models in which to study the development and
behavior of enriched or mixed populations of primary brain cells, including neurons, astrocytes,
oligodendroglia, microglia and endothelia. These cells originate in genetically manipulated rodents or they are
normal cells exposed to environmental stimuli, including drugs and toxins. The Tissue Culture Service and
Stem Cell Service interact closely, since they share several in vitro methodologies and serve as a conduit to
drive and help design rodent behavior testing.
The PMC emphasizes training of users and their staff. Trained users can continue studies in their own
laboratory or they can utilize the equipment in the PMC at reduced cost. This core interacts with others in the
Center. It will exchange protocols, services and best practices with other IDDRCs in the Network.
Relevance to IDDRC Mission: The PMC bridges all three domains of “Genes, Brain, and Behavior”, the theme
of the CHOP/Penn IDDRC (see Overall: Overview of Center). The Core was developed in response to a user
survey (2014) that emphasized a need for an IDD-focused facility for the study of mammalian behavior and
one to address the potential of current stem cell technologies, including CRISPR-Cas.
Eligibility: These services are available both to approved users of the IDDRC at CHOP/UPenn and to users at
other Centers in the Network.

## Key facts

- **NIH application ID:** 9831585
- **Project number:** 5U54HD086984-05
- **Recipient organization:** CHILDREN'S HOSP OF PHILADELPHIA
- **Principal Investigator:** EDWIN TED G. ABEL
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $152,876
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9831585

## Citation

> US National Institutes of Health, RePORTER application 9831585, Preclinical Models: Core F (5U54HD086984-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9831585. Licensed CC0.

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