# Clinical Translational: Core B

> **NIH NIH U54** · CHILDREN'S HOSP OF PHILADELPHIA · 2020 · $136,871

## Abstract

(CLINICAL TRANSLATIONAL CORE(CTC): CORE B)
PROJECT SUMMARY
Description: The Clinical Translation Core (CTC) provides investigators with a set of services to enhance the
productivity of Intellectual and Developmental Disability (IDD) clinical translational researchers. The CTC
focuses on the effective and rapid collection of IDD study populations that are of adequate size and well-
characterized. IDDs are highly variable disorders that result from heterogeneous genetic factors which affect
brain function in a non-uniform manner. Scientific progress demands that each IDD be well characterized and
stratified along more than one dimension in order to control for a degree of clinical heterogeneity that otherwise
could confound progress in developing therapies. The CTC addresses this challenge by providing a host of
approaches to enable recruitment of very large samples that are well-characterized across relevant
dimensions. These supports include (a) Creating new websites for individual projects that will serve as both a
recruitment portal and as a mechanism to enable online IRB consent and collection of “light phenotyping”
through use of a common IDD library of questionnaires; (b) Mining the CHOP/Penn electronic health record
for recruitment and for study data; (c) Creation of a shared IDD database that is common to all IDDs
investigated at our institutions. This shared database will facilitate secondary analyses that discriminate clinical
features specific to a particular IDD; and (d) The coordination of the many existing clinical translational
resources at CHOP/UPenn, in order to carry out the CTC's aims in the most cost effective manner, and amplify
its effectiveness. The CTC also provides expert consultation with (a) gold standard clinician administered
assessments, as well as (b) deep phenotyping via a host of novel, technology based approaches for
quantifying behavior (e.g., eye tracking, motion capture, use of on online computer adaptive tests). In addition
to these crucial supportive roles, the CTC will foster new clinical investigation by creating an infrastructure
that will be available to future investigators, which will simplify their entrée to high-quality human research.
Relevance to IDDRC Mission: Then CTC is of fundamental importance to the mission of the IDDRC as it
facilitates interdisciplinary and translational research in IDD. It is a vital component of the CHOP/UPenn
Center's goal of advancing the diagnosis, prevention, treatment, and amelioration of IDDs. The CTC helps
bridge all three domains of the organizing theme of the CHOP/Penn IDDRC (see Overall: Overview of Center):
“Genes, Brain, and Behavior”. By centrally focusing on quantifying behavior, as well as facilitation of biosample
collection, it is integral the process of successfully understanding and treating the biological bases of the
behavioral manifestations of IDD.
Eligibility: These services are available both to approved users of the IDDRC at CHOP/UPenn and to appr...

## Key facts

- **NIH application ID:** 9831587
- **Project number:** 5U54HD086984-05
- **Recipient organization:** CHILDREN'S HOSP OF PHILADELPHIA
- **Principal Investigator:** ROBERT Thomas SCHULTZ
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $136,871
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9831587

## Citation

> US National Institutes of Health, RePORTER application 9831587, Clinical Translational: Core B (5U54HD086984-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9831587. Licensed CC0.

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