# Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions

> **NIH NIH R01** · TULANE UNIVERSITY OF LOUISIANA · 2020 · $642,090

## Abstract

Abstract
Considerable interpersonal variability in weight loss exists among participants in diet interventions. Traditional
one-size-fits-all intervention strategy generally neglects such variation, leading to lower effectiveness; however
our currently knowledge on the intrinsic factors affecting interpersonal variability is extremely poor. The
proposed systems study aims to fill this significant research gap, to identify novel in-built factors that
determine interpersonal variability in diet interventions. In two of the largest and most comprehensive
comparator trials on the popular weight-loss diets - POUNDS LOST (N=811) and DIRECT (N=322), we
propose to identify novel circulating microRNAs (miRNAs) on whole genome scale associated with 2-year
weight loss in response to diet interventions. We will also prospectively examine effects of weight-loss diet
interventions varying in macronutrient compositions on dynamic changes in serum miRNAs; and examine the
relations between miRNAs and markers regulating energy intake and expenditure. In addition, we will apply
newly-developed multi-omics algorithm to predict weight loss, by integrating miRNAs with genomics,
metabolomics, biochemical and clinical measures. We have assembled a solid group of experienced
collaborators with expertise in Nutrigenetics and Nutrigenomics, bioinformatics, diet interventions and
biostatistics. We believe that our study will provide novel insights into the roles of miRNAs in determining
weight loss in response to diet interventions, and contribute significantly to improve efficiency of precision
obesity management.

## Key facts

- **NIH application ID:** 9832658
- **Project number:** 5R01DK115679-03
- **Recipient organization:** TULANE UNIVERSITY OF LOUISIANA
- **Principal Investigator:** Lu Qi
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $642,090
- **Award type:** 5
- **Project period:** 2018-01-01 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9832658

## Citation

> US National Institutes of Health, RePORTER application 9832658, Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions (5R01DK115679-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9832658. Licensed CC0.

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