# University of California San Diego Neuroscience Microscopy Imaging Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $373,223

## Abstract

The ability to test hypotheses in a variety of neuroscience fields has expanded exponentially due to new and
emerging technologies that detect and probe molecular, cellular and physiological events in terminally
collected samples or living model organisms with ever increasing power and capabilities. Supported by an
NINDS P30 grant since 2003, the University of California San Diego Neuroscience Microscopy Imaging Core
has grown into a world-class core and a centerpiece for local neuroscience research. Importantly, the Core
serves an otherwise unmet neuroscience research need in microscopy imaging of many laboratories. Its
existence has resulted in remarkable yields in productivity, expanded scientific scope and ability to test
hypotheses using cutting edge technologies. In this application, we seek to acquire a Zeiss Lightsheet Z.1
microscope for fast, gentle, multiview imaging deep into thick samples such as cleared brain and spinal cord
tissue blocks or living organisms. The requested system was chosen because of the high quality of data that it
generates, unsurpassed abilities to document events in the nervous system not previously feasible and its
ease of use, which is critical for a multi-user core. In addition, we ask for funds to help maintain, operate and
support a number of existing cutting edge imaging tools at the Core. On top of 35 NINDS-funded Major User
labs with 44 qualifying projects, a wider base of neuroscience investigators benefit from access to our Core.
UCSD is a leading institution in neuroscience research, with our neuroscience graduate program consistently
ranked among the top in the nation. The strong support of local neuroscience researchers along with that of
institutional leadership, the synergies and the economies of scale that the Core has created and the continued
P30 grant support will ensure the future success of our Core. In return, our Core supports the mission of the
NINDS by serving a wide range of outstanding research programs that aim to gain fundamental knowledge of
the nervous system and to reduce the burden of neurological diseases.

## Key facts

- **NIH application ID:** 9832679
- **Project number:** 5P30NS047101-17
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** JOSEPH G GLEESON
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $373,223
- **Award type:** 5
- **Project period:** 2003-09-30 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9832679

## Citation

> US National Institutes of Health, RePORTER application 9832679, University of California San Diego Neuroscience Microscopy Imaging Core (5P30NS047101-17). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9832679. Licensed CC0.

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