# Microscopy

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $200,468

## Abstract

ABSTRACT-Microscopy (MICRO) Shared Resource 
The Microscopy Shared Resource (MICRO) is a CCSG basic shared resource that combines the expertise 
and equipment from three different imaging modalities: light microscopy, intravital microscopy and electron 
microscopy. This combination gives LCCC members access to outstanding imaging capabilities. Visualization 
of the process of oncogenesis from tumors in whole organs, to cancer cells invading normal tissues, to 
transformed cells growing in culture and finally visualization of the macromolecules which lie at the heart of 
transformation provides a critical means of understanding, manipulating, and ultimately combating cancer. 
Having a broad range of imaging tools immediately available to the cancer research community at UNC within 
the LCCC is essential if the diverse research of the many cutting edge studies are to progress rapidly toward 
their goals in cancer research. This requires specialized techniques spanning a range of visualization that 
encompasses light and electron microscopy and dimensions of millimeters to nanometers. To provide this 
technology to the LCCC members, three highly specialized laboratories work together and each has an 
excellent history of accomplishments. The three components of the LCCC Microscopy SR consist of: The 
Microscopy Services Laboratory (MSL) which stands as the main supplier of widefield, confocal, and live cell 
imaging plus image analysis and morphometry. The Intravital Imaging SR provides a unique set of 
microscopes and expertise for imaging cells, tissues and organs within a living animal. The Electron 
Microscopy SR provides specialized imaging techniques for macromolecular imaging that have been 
developed by the SR director and are used world wide. Taken together, these three SRs provide a powerful 
tool for our cancer researchers. Future directions include expansion of light microscopy into the realm of 
super-resolution imaging and establishment of new methods for tagging specific proteins such that they can be 
localized in cells by high resolution thin sectioning.

## Key facts

- **NIH application ID:** 9834849
- **Project number:** 5P30CA016086-44
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** JAMES E BEAR
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $200,468
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9834849

## Citation

> US National Institutes of Health, RePORTER application 9834849, Microscopy (5P30CA016086-44). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9834849. Licensed CC0.

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