# Structural Biology

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $111,870

## Abstract

ABSTRACT- Structural Biology (STRBIO) Shared Resource 
The Structural Biology shared resource is a ‘super core’ in the basic group that provides an integrated 
platform of expertise, education, and infrastructure that creates an accessible environment for LCCC 
researchers to undertake structural biology projects. The Core specializes in three major branches of structural 
biology: high-resolution studies using X-ray crystallography, multi-dimensional nuclear magnetic resonance 
spectroscopy and structural bioinformatics and computational methods. These areas are complemented by our 
recent investments for the streamlined production of purified and functional proteins for structural work. The 
Core provides state-of-the-art equipment and specialized expertise to guide users through any and all stages 
of structure determination projects: homology modeling, construct design, protein expression & purification, 
crystallization, structure determination, structure analysis, biophysical studies, molecular dynamics studies, 
presentation & publication. These services are being used by LCCC researchers to understand fundamental 
cellular processes that contribute to cancer. From a more translational perspective, the STRBIO is also 
instrumental for the support of LCCC researchers undertaking efforts to develop drugs and macromolecular 
therapeutics. This support derives from our capacity to produce atomic-resolution structures of macromolecular 
targets bound to lead compounds, as well as our capacity to produce large amounts of protein reagents for 
high-throughput screens and biological studies. The Core is led by a team of highly experienced structural 
biologists with proven track records in cancer-related research. During the fiscal year ending July 2014, the 
STRBIO was used by 35 LCCC members which was 85% of total usage and an 80% increase in users relative 
to the equivalent period in 2009 to 2010 and corresponding to the last competitive renewal of this application. 
Highlights for the STRBIO during the last funding period include extensive expansion of our protein production 
and purification services, the integration of these services with our macromolecular X-ray crystallography core 
in newly renovated space, and the acquisition of an 850 MHz NMR spectrometer necessitating the relocation 
of our NMR facilities into the newly built Marsico Hall. These studies include high-impact research published by 
LCCC members in top-tier journals, including: ACS Med. Chem., Science, Nat. Struct. Mol. Biol., PNAS, Nat. 
Chem. Biol., and Sci. Signal. For 2015, the LCCC requests $81,088 to support proteins expression and 
purification efforts. CCSG funds are projected to be 14% of operating costs.

## Key facts

- **NIH application ID:** 9834852
- **Project number:** 5P30CA016086-44
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** JOHN E SONDEK
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $111,870
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9834852

## Citation

> US National Institutes of Health, RePORTER application 9834852, Structural Biology (5P30CA016086-44). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9834852. Licensed CC0.

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