# Analytical Chemistry & Pharmacology

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $107,367

## Abstract

ABSTRACT- Analytical Chemistry and Pharmacology (ACP) Shared Resource 
The goals of the Analytical Chemistry and Pharmacology SR (ACP) are to support the translational 
development of small molecule, nanoparticle and biological anticancer agents via analytical chemistry and 
pharmacologic infrastructure, methodologies and expertise. The expansion of the Molecular Therapeutics 
Program, development of preclinical models to evaluate anticancer agents, the opening of the new North 
Carolina Cancer Hospital’s (NCCH) Clinical Trials Unit (CTU) and recruitment of additional faculty members to 
the UNC LCCC and Carolina Institute for NanoMedicine (CINM) created increased demand for applied and 
translational pharmacology services. This SR is comprised of the Translational Oncology and Nanoparticle 
Drug Development Initiative (TOND2I) Lab and the sample processing lab located in the NCCH CTU. The SR 
develops and validates analytical assays in biological solutions, analyzes samples, performs pharmacokinetic 
and pharmacodynamic analyses of data for small molecule agents and provides specialized methods to 
evaluate the pharmacology of carrier-mediated agents (e.g. nanoparticle, conjugates, antibody drug 
conjugates) and biologics. The ACP supports studies throughout the UNC LCCC with extensive use by the 
Breast Cancer, Molecular Therapeutics, Cancer Cell Biology, Immunology and Clinical and Translational 
Research programs in the UNC LCCC. In addition, the ACP has significant collaborations with UNC LCCC 
members that are also part of the Carolina Institute for NanoMedicine (CINM), Carolina Center for Cancer 
Nanotechnology Excellence (C-CCNE) and the Center for Integrative Chemical Biology and Drug Discover 
(CICBDD), Center for Nanotechnology in Drug Delivery (CNDD) and the Center for Pharmacogenomics and 
Individualized Therapy (CPIT) in the UNC School of Pharmacy. The SR is currently being used by 14 
investigators, 74% of whom are peer reviewed cancer center members. The total budget for the SR is 
$588,141 and $77,823 (13% of the total budget) is requested from the CCSG. Future plans are to expand the 
research of UNC LCCC members, develop novel pharmacologic methods and platforms and use the resources 
of this SR to recruit novel anticancer agents to UNC translational and clinical development.

## Key facts

- **NIH application ID:** 9834854
- **Project number:** 5P30CA016086-44
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** WILLIAM C ZAMBONI
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $107,367
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9834854

## Citation

> US National Institutes of Health, RePORTER application 9834854, Analytical Chemistry & Pharmacology (5P30CA016086-44). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9834854. Licensed CC0.

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