# Genomics

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $351,743

## Abstract

ABSTRACT – Sequencing and Genomics (GEN) Shared Resource 
The Sequencing and Genomics Shared Resource (GEN SR) is a ‘super SR’ that provides an integrated 
platform of technology, expertise, education, and infrastructure creating an accessible environment for LCCC 
researchers to design and undertake cutting edge genomics projects. This SR is led by a team of highly 
experienced genomic biologists with proven track records in cancer-related research. The SR specializes in 
five major technologies: Agilent Microarrays, Affymetrix Microarrays, Illumina bead array genotyping, NextGen 
sequencing (Illumina, PacBio, and Ion Platforms) and RNAi screening for functional validation. These areas 
are complemented by major LCCC investments in computational infrastructure and analysis. The SR provides 
state-of-the-art equipment and specialized expertise to guide users through any and all stages of a project: 
consultation, sample QC, data generation, and analysis. These services are being used by LCCC researchers 
to understand fundamental cellular processes that contribute to cancer. For example, these facilities have 
contributed extensively to the data generated at UNC as part of The Cancer Genome Atlas project. 
Additionally, several groups are using these SRs to translate cancer genomic information into actionable 
clinical data as part of the NCGENES and UNCseq projects. In addition to an increase in these translational 
projects, we expect that the next five years there will be increased demand for integrative genomics projects 
that generate data from a variety of sources and SRs and then, working with the Bioinformatics Shared 
Resource teams, produce comprehensive analyses of tumor samples. 
From the end of June 2013 to July 2014, the GEN SR was used by 96 LCCC members (85% of total use). 
Since 2009 use of this combined facility has nearly tripled (measured in terms of grant and recharge dolla rs). 
Highlights for the GEN SR during the last funding period include extensive expansion of our NextGen 
sequencing services and automation of all array platforms, as well as relocation to a new shared facility space 
custom renovated to support the specific infrastructure required to run these systems 24/7. As a result, in 
fiscal year 2013-2014 alone this SR made 13,303 genomic libraries, sequenced over 100 Trillion bp, 
genotyped 1,945,409,504 SNPs, and ran 13,517 microarray experiments. This work has contributed to over a 
hundred publications, including seven in Nature as part of The Cancer Genome Atlas project. For 2015, the 
LCCC requests $254,659 to maintain personnel to support genomics efforts and offset service contract costs. 
CCSG funds are projected to be 4% of operating costs.

## Key facts

- **NIH application ID:** 9834859
- **Project number:** 5P30CA016086-44
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Corbin D Jones
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $351,743
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9834859

## Citation

> US National Institutes of Health, RePORTER application 9834859, Genomics (5P30CA016086-44). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9834859. Licensed CC0.

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