# Cancer Cell Biology Research Program (Program 1)

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $38,649

## Abstract

ABSTRACT 
The overarching goals of the Cancer Cell Biology Program are: (i) to understand, at the molecular and cellular 
levels, mechanisms underlying tumor initiation, progression, metastasis and resistance to therapeutic 
treatment, and (ii) to identify and validate new targets for cancer therapy. Insight derived from these studies, 
when integrated with research and development from other programs, will provide targets and guidance for the 
development of strategies for therapeutic intervention of cancer. Toward these two goals, the Program faculty 
investigates various aspects of cancer cell biology, including growth factors and receptors; angiogenesis and 
vascular biology; apoptosis; cell cycle regulation; chromatin biochemistry and transcriptional regulation; cell 
microstructure and function; DNA replication and repair; metabolism; regulatory RNA; and signal transduction. 
Led by two co-leaders with complementary expertise, Yue Xiong and James Bear, the program organizes 
these different areas into four major research themes: (1) Cell Cycle, (2) Cell Signaling, (3) Cell Movement and 
Organization, and (4) Epigenetics and Chromatin Biology. The major emphasis of the Program is to foster 
integrated research that spans these inter-related themes, enhancing the research and translational 
capabilities of program investigators through the establishment, expansion and utilization of appropriate core 
facilities, and promoting interactions with investigators from other LCCC basic, clinical and population sciences 
programs. 
The Cancer Cell Biology Program consists of 45 members who are associated with 7 basic science and 4 
clinical departments at UNC-Chapel Hill. During the last funding period, program members have published 644 
cancer-related articles (30% collaborative). In 2014, our program members held 101 grants and $27.3M (total 
cost) in annual extramural funding, including 24 grants and $5.8M (total costs) from the NCI.

## Key facts

- **NIH application ID:** 9834870
- **Project number:** 5P30CA016086-44
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** YUE XIONG
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $38,649
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9834870

## Citation

> US National Institutes of Health, RePORTER application 9834870, Cancer Cell Biology Research Program (Program 1) (5P30CA016086-44). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9834870. Licensed CC0.

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