# Cancer Genetics Research Program (Program 5)

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $39,438

## Abstract

Abstract 
The Cancer Genetics Program within the UNC Lineberger Comprehensive Cancer Center (LCCC) was 
established in 2001 to facilitate an integrated, multi-disciplinary approach to research and clinical care. It is 
comprised of laboratory-based investigators, statistical geneticists, researchers and clinicians, all focused on 
improving our understanding and treatment of cancer. By integrating the multiple strengths of UNC, ranging 
from basic science to clinical genomic analysis, the LCCC Genetics Program has become a world leader in 
using genome-scale sequencing technology to address critical clinical questions related to cancer. Treatments 
will increasingly be tailored to an individual's genomic constitution and genomic characteristics of their tumor, 
mitigating toxicity and enhancing efficacy through individually tailored treatment and precise targeting of the 
mutations that drive tumor propagation. We have developed a comprehensive program that includes: (i) 
utilizing diverse experimental organisms from yeast, worm and mouse, to cell-based systems and ultimately 
human populations with the overarching goal of identifying mechanisms that result in genomic changes and the 
specific lesions responsible for cancer phenotypes; (ii) use of Whole Genome, Whole Exome and Whole 
Transcriptome Sequencing (WGS/WES/WTS) as effective diagnostic tools; (iii) facilitating the effective use of 
genomic information by patients and providers through structured categorization of genomic variation based 
upon clinical validity and utility; (iv) a state-of-the-art informatics approach that incorporates generation, 
analysis, and management of genomic data with coupling of genomic and clinical information to drive both 
clinical testing and translational research; (v) development of ethical and practical policies for the use of WGS 
data by both patients and clinicians; and (vi) exploration of massively parallel sequencing in a public health 
context through sequencing of selected, highly actionable genes in members of the general population for 
cancer-prevention purposes. 
Our vision has been realized through value added LCCC resources for strategic recruitment of faculty in 
emerging fields, investment in cutting-edge technology, enhanced organizational capability for integrative 
analysis and the securing of significant federal funding to enable the application of genomics to diverse 
aspects of cancer care and prevention. This unified and integrated effort ensures that insights gained through 
basic research do not linger in the lab but will lead directly as possible to application in humans. Such an 
integrated approach is critical for understanding the genesis, progression, and treatment of cancer. 
There are 29 program members from 10 different departments (6 departments in the School of Medicine, 2 in 
the School of Public Health, 2 in the College of Arts and Sciences). During the last funding period, program 
members have published 627 cancer-r...

## Key facts

- **NIH application ID:** 9834875
- **Project number:** 5P30CA016086-44
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** TERRY R MAGNUSON
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $39,438
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9834875

## Citation

> US National Institutes of Health, RePORTER application 9834875, Cancer Genetics Research Program (Program 5) (5P30CA016086-44). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9834875. Licensed CC0.

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