# Shared Resource: Pharmacology

> **NIH NIH P30** · WAYNE STATE UNIVERSITY · 2020 · $77,250

## Abstract

ABSTRACT 
The Pharmacology Core's mission is to provide state-of-the-art bioanalytic technology and a broad range of 
pharmacology expertise to enable evaluation of critical pharmacological endpoints in clinical trials and 
preclinical studies. The Pharmacology Core is grouped in the Cross Disciplinary Research Core Cluster 
which, in addition to the Pharmacology Core, includes the Biostatistics, Genomics, and the Biobanking 
and Correlative Sciences Cores. 
Two services, Biospecimen Processing and Bioanalysis, are provided on a fee-for-service basis. Biospecimen 
Processing is a centralized resource for the acquisition, processing, and shipment of patient specimens 
(including blood and bone marrow samples) that are required for evaluation of pharmacokinetics or 
pharmacodynamics according to clinical protocol specifications to facilitate and support clinical and laboratory 
research. Bioanalysis provides development, validation and implementation of high-performance liquid 
chromatography (HPLC)-based analytical methods for quantitative measurement of drugs, metabolites, or 
endogenous compounds in biological samples (including biofluid, tissue and cell culture samples). In addition, 
a broad range of pharmacology support is provided, including: 1) pharmacokinetic study design; 2) 
pharmacokinetic data analysis and modeling using traditional compartmental and non-compartmental analysis, 
nonlinear mixed-effect (population) pharmacokinetic modeling, and physiologically based pharmacokinetic 
modeling; 3) in vitro drug metabolism studies; 4) metabolite identification; and 5) determination of drug plasma 
protein binding and plasma-to-blood ratio. 
The Core is equipped with state-of-the-art analytical instruments (such as the AB SCIEX QTRAP 6500 LC- 
MS/MS system) and pharmacokinetic analysis software. The laboratory is centrally located with convenient 
access for all KCI investigators. 
The services provided by the Pharmacology Core have contributed to 92 peer-reviewed publications during 
the current review period.

## Key facts

- **NIH application ID:** 9836639
- **Project number:** 5P30CA022453-38
- **Recipient organization:** WAYNE STATE UNIVERSITY
- **Principal Investigator:** Jing Li
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $77,250
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9836639

## Citation

> US National Institutes of Health, RePORTER application 9836639, Shared Resource: Pharmacology (5P30CA022453-38). Retrieved via AI Analytics 2026-05-31 from https://api.ai-analytics.org/grant/nih/9836639. Licensed CC0.

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