# Pediatric Oncology Research Program

> **NIH NIH P30** · UNIVERSITY OF PENNSYLVANIA · 2020 · $75,137

## Abstract

Project Summary 
The Pediatric Oncology Program has been continuously approved in the NCI Cancer Center Support Grant 
since 1992. The mission of the Program is to discover and develop targeted, rational treatment approaches to 
improve cure rates and reduce acute and long-term toxicities in children with cancer. The Programmatic goals 
are: 1) to define the genetic and cellular alterations involved in the pathogenesis of childhood cancers and to 
translate these discoveries into new diagnostics, biomarkers and therapeutic targets; 2) to develop and 
clinically test new immunotherapies that target tumor-specific antigens on childhood cancers; 3) to improve 
outcomes for childhood cancers by designing and conducting clinical trials of biologically targeted therapies, 
and by developing more rational methods of administering conventional therapies using pharmacokinetics and 
pharmacoepidemiology; and 4) to develop approaches to minimize the acute and long-term adverse effects of 
cancer treatment in children and adolescents using an integrated research approach incorporating 
psychosocial, survivorship and cancer control outcome measures. This Program was rated as “Outstanding to 
Exceptional” at the time of the 2010 CCSG renewal application and is led by Frank Balis, MD, Professor of 
Pediatrics and Director of Clinical Cancer Research and Garrett Brodeur, MD, Professor of Pediatrics and 
Associate Director for Pediatric Research at the Abramson Cancer Center. Drs. Balis and Brodeur are 
experienced researchers and national leaders in childhood cancer research. The Pediatric Oncology Program 
has fully integrated basic, translational, and clinical research components, with a diverse group of investigators 
who have expertise and research efforts in cancer genomics, cell biology and signal transduction, tumor 
immunology and immunotherapy, drug development, clinical pharmacology, epidemiology, clinical research, 
cancer control, survivorship, and behavioral oncology. The Program is fully integrated into the Cancer Center. 
Pediatric oncologists are members of four other Programs, and Program members collaborate with 
investigators from five of the other Programs. The Pediatric Oncology Program is an international leader in 
clinical research and serves as the lead institution for the COG NCI Chair's grant. The 35 Program members 
represent five departments in the Perelman School of Medicine and have $16M in annual research grant 
funding, of which $6.4M is peer-reviewed and $2M is NCI-funded. There have been a total of 443 cancer- 
related publications from the Program since 2010. Of these, 35% are intra-Programmatic, 14% resulted from 
inter-Programmatic collaboration, and 71% are multi-institutional.

## Key facts

- **NIH application ID:** 9836835
- **Project number:** 5P30CA016520-44
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** STEPHAN A. GRUPP
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $75,137
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9836835

## Citation

> US National Institutes of Health, RePORTER application 9836835, Pediatric Oncology Research Program (5P30CA016520-44). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9836835. Licensed CC0.

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