# PROTOCOL REVIEW AND MONITORING SYSTEM (Core 012)

> **NIH NIH P30** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $156,405

## Abstract

Project Summary/Abstract 
The USC Norris Protocol Review and Monitoring System (PRMS) has two organizational components, the 
Clinical Investigations Committee (CIC) and the Scientific Progress and Accrual Monitoring Subcommittee. 
During the project period, PRMS has been significantly improved, resulting in reduced turnaround time and 
fewer low accruing trials. Members of the CIC now represent a broad range of scientific disciplines and the 
clear majority is senior investigators. To assure quality reviews, we have clarified member selection criteria and 
term limit policies. We have also increased the frequency of CIC meetings and attendance rates, enhanced 
scientific review and prioritization processes, improved written communications with PIs, and added maximum 
PI response times to reduce delays. A new operational and financial review process has been added and 
integrated into the PRMS workflow to assure operational feasibility without increasing turnaround. These and 
other improvements have improved quality in the initial scientific review process and halved time to PRMS 
approval, which averages four weeks. To enhance scientific monitoring of approved trials and to close trials 
that are not achieving their enrollment targets more quickly, we formed a dedicated Scientific Progress and 
Accrual Monitoring Subcommittee. The resulting structure completely separates scientific review and quality 
assurance. With this organizational change, an existing accrual monitoring policy was tightened so that we can 
close trials that are consuming institutional resources and are not enrolling at a reasonable pace. In summary, 
the current PRMS process is highly effective in selecting and supporting investigator initiated trials and recent 
changes having a very positive impact on both quality and efficiency. Additional improvements will be achieved 
as OnCore is fully implemented and longer-term results are realized.

## Key facts

- **NIH application ID:** 9838175
- **Project number:** 5P30CA014089-45
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** CARYN LERMAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $156,405
- **Award type:** 5
- **Project period:** 2019-12-01 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9838175

## Citation

> US National Institutes of Health, RePORTER application 9838175, PROTOCOL REVIEW AND MONITORING SYSTEM (Core 012) (5P30CA014089-45). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/9838175. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*