# Translational and Clinical Sciences Research Program (Project-007)

> **NIH NIH P30** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $52,780

## Abstract

The Translational and Clinical Sciences Program enables USC Norris discoveries to be translated to the clinic 
by conducting innovative trials relevant to our patient population. Members have diverse expertise from basic 
to clinical investigation and are highly engaged. Leadership is enriched by an inter-programmatic Steering 
Committee, which leverages expertise in genomics, biomarkers, bio-imaging and drug development, and 
regular meetings with disease and thematic teams to ensure that translational and clinical research occurs in 
an interdisciplinary and coordinated manner. New targets are selected from basic science Research Programs, 
with translation supported and accelerated by collaborative teams focused on developing novel therapeutics, 
diagnostics and biomarkers and on executing clinical trials. Members actively participate in intra- and interprogrammatic 
research using the expertise of USC Norris Shared Resources and clinical resources. Priority 
themes are novel targets, enhanced efficacy of antibodies using drug conjugates, immunotherapeutics, and 
cell therapies, and epigenetic targets. We have identified and validated tumor-associated targets, developed 
agents that have been taken to first in human studies, developed companion imaging agents, and initiated 
multiple high priority investigator initiated trials. Several novel targets have been chosen and moved through 
different stages of translation that are already or soon to be in the clinic. Accompanying biomarkers and 
imaging probes have also been developed for several targets and integrated into trials. Multiple high-impact 
trials have been conducted, including first in human novel agents discovered and developed at USC Norris and 
positive Phase II trials that have moved to Phase III. USC Norris PIs have served as lead investigators for 
several multicenter Phase III NCTN trials. The Program’s 61 members come from six schools and 21 
departments. They have $16M in total funding (direct costs) of which 31% is from NCI, 25% is from other NIH 
sources, and 13% from other peer-reviewed funding sources. The Program has been highly productive with 
1,030 publications during the project period, of which 27% were intra-programmatic, 31% were interprogrammatic 
and 42% were inter-institutional.

## Key facts

- **NIH application ID:** 9838182
- **Project number:** 5P30CA014089-45
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** CARYN LERMAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $52,780
- **Award type:** 5
- **Project period:** 2019-12-01 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9838182

## Citation

> US National Institutes of Health, RePORTER application 9838182, Translational and Clinical Sciences Research Program (Project-007) (5P30CA014089-45). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/9838182. Licensed CC0.

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