# Integrated Translational Research Core

> **NIH NIH P30** · UNIVERSITY OF CHICAGO · 2020 · $170,801

## Abstract

PROJECT SUMMARY/ABSTRACT
Over the past 75 years, researchers in digestive diseases at the University of Chicago have made crucial
advances in the understanding of clinical disease behavior and progression, therapeutic efficacy, disease
monitoring, cost-effectiveness assessment, genetics of IBD, epigenetics of IBD, microbial influences on
gastrointestinal function, immune mechanisms, normal physiology and pathogenesis of luminal diseases. The
investigators in the DDRCC have increasingly recognized that a comprehensive understanding of the clinical
behavior, phenotype, epidemiology and pathophysiology of human disease requires the analysis of clinical
data, analysis of human cells and tissues and the establishment/advancement of human model systems and
cellular experiments. The ITR core was created to enable translational research by providing the infrastructure
and means to integrate clinical information with experimental data relating to the microbiota, the intestinal
tissue, the immune system and the genetic and epigenetic make-up. The ITR Core has the singular goal of
establishing a centralized service to provide consultative and hands-on technical expertise to conduct
associated human studies, key clinical database information that could be used for clinical trials
recruitment, outcomes analysis, therapeutic efficacy studies, and in conjunction with biospecimen
recruitment, a source of well-phenotyped samples as reagents for basic science and translational
research. The Specific Aims of the ITR Core are summarized as follows: (1) to provide services for human
biospecimen-based study design and cellular analysis; (2) to provide the infrastructure and services to optimize
clinical database utilization and (3) to provide the infrastructure and services to optimize human biospecimen
utilization. In particular, the ITR Core has worked steadfastly to optimize consultation services for human study
design, create a dynamic mechanism to access and assess clinical data and to create an efficient workflow for
patient and biospecimen recruitment. All improvements have been integrally supported by the University of
Chicago and collaborative resources to address the needs of DDRCC investigators and to create an ITR Core
that functions as a critical resource for the other DDRCC Cores. Since September 1, 2009, 27 DDRCC
members (53% of membership) have utilized the ITR Core and 2568 Genesys IBD Registry and 603
Celiac Disease Registry patients have been recruited, with a total of 4477 patient recruited through the ITR
Core for all GI studies in the past 5 years. The ITR Core has also built a repository of biospecimens to facilitate
the rapid generation of data which includes 16,291 biospecimens on 1002 patients, including whole blood DNA,
serum, biopsy RNA, biopsy DNA, flash frozen biopsy samples and FFPE tissues. The ITR core will continue to
build on the infrastructural foundation established over the last 4 years to meet the growing and changing
needs of DD...

## Key facts

- **NIH application ID:** 9838213
- **Project number:** 5P30DK042086-30
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** BANA JABRI
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $170,801
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9838213

## Citation

> US National Institutes of Health, RePORTER application 9838213, Integrated Translational Research Core (5P30DK042086-30). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9838213. Licensed CC0.

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