# Functional Interactions of Cardiac Ion Channels

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $481,970

## Abstract

Abstract
 Our laboratory was the first to demonstrate unequivocally that several isoforms of small conductance Ca2+-
activated K+ channels (SK or KCa2 channels) underlie Ca2+-activated K+ current (IK,Ca) in cardiomyocytes.
Indeed, interests in cardiac SK channels are fueled by recent studies suggesting the possible roles of SK
channels in human atrial fibrillation (AF) and up-regulation of SK channels in heart failure (HF). Therefore, SK
channel may represent a novel therapeutic target for cardiac arrhythmias.
 Even though the activation and trafficking of SK channels are Ca2+-dependent, the Ca2+ source remains
undefined. In addition, the Ca2+-dependence of SK channels is inextrictably linked to calmodulin (CaM), whose
mutations have been shown to be associated with human arrhythmias. Since CaM is ubiquitous, it is
paramount to disentangle the web of CaM-regulated ion channels from the roles of SK channels in
calmodulinopathy. Moreover, SK channel expression is upregulated in HF but the exact mechanisms remain
incompletely understood. Blockade of SK channels has been shown to be both anti-arrhythmic and
proarrhythmic in various models. These aforementioned challenges are the premises of the present proposal.
Thus, the essence of this proposal is to deploy innovative imaging, functional analyses, and molecular
modeling to address successively the regulation of cardiac Ca2+-activated K+ channels in normal and failing
cardiac myocytes.

## Key facts

- **NIH application ID:** 9838765
- **Project number:** 5R01HL085844-12
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Nipavan Chiamvimonvat
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $481,970
- **Award type:** 5
- **Project period:** 2007-04-15 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9838765

## Citation

> US National Institutes of Health, RePORTER application 9838765, Functional Interactions of Cardiac Ion Channels (5R01HL085844-12). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9838765. Licensed CC0.

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