# Development and Maintenance of Software for MR Spectroscopic Imaging

> **NIH NIH R01** · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2020 · $239,878

## Abstract

The MIDAS (Metabolic Imaging Data Analysis System) software package provides unique
functionality for processing, display, and analysis of MR Spectroscopic imaging (MRSI) data,
and includes close integration with structural MRI and other imaging modalities. This system
supports processing for a volumetric echo-planar spectroscopic imaging (EPSI) acquisition that
enables mapping of tissue metabolites and is of particular value for multiparametric in vivo
imaging studies of the brain. The EPSI and MIDAS software have been distributed to multiple
sites worldwide and are being used for multiple neuroimaging research applications. Under
three specific aims, this project will maintain and develop new functionality for these packages.
Aim 1 will add new spectroscopy and image processing functions, which will extend statistical
image analyses, improve performance of spectral analysis for overlapping signal contributions,
and implement improved methods for brain temperature mapping. Aim 2 will support the EPSI
acquisition through future system upgrades, add motion correction, extend spatial sampling
acceleration, implement multi-echo sampling for improved sampling accuracy, and enable
studies at higher field strengths. Studies at 7 Tesla will evaluate these methods for mapping of
additional brain metabolites. Aim 3 will support dissemination of the developed software
products with continued development of user documentation, educational materials and
seminars, and maintain the project web site. Through these aims, this project will provide
continued support and development for a highly innovative suite of functions that facilitate
clinical and basic biomedical imaging research studies using MRI and MRSI.

## Key facts

- **NIH application ID:** 9840471
- **Project number:** 5R01EB016064-07
- **Recipient organization:** UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- **Principal Investigator:** Andrew A. Maudsley
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $239,878
- **Award type:** 5
- **Project period:** 2013-09-20 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9840471

## Citation

> US National Institutes of Health, RePORTER application 9840471, Development and Maintenance of Software for MR Spectroscopic Imaging (5R01EB016064-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9840471. Licensed CC0.

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