# Core A: Administrative Core

> **NIH NIH P42** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $231,034

## Abstract

ABSTRACT: ADMINISTRATIVE CORE
The Administrative Core is the driver for the planning and coordination of all activities within the University of
North Carolina Superfund Research Program (UNC-SRP). It ensures that the research aligns with our
overarching mission-to develop new solutions for iAs reduction and disease prevention through
mechanistic and translational research. The role of the Administrative Core is to oversee and facilitate the
conduct of work within the UNC-SRP to ensure responsiveness to the SRP mandates. In addition to fulfilling
mandates of the SRP program, we implement research that is in line with the 2018-2023 NIEHS Strategic Plan.
This Core oversees the nine other components of the UNC-SRP. Projects 1-3 use highly translational techniques
spanning in vitro and in vivo models, and human populations to understand mechanisms of iA-induced metabolic
dysfunction/diabetes. Projects 4-5 advance the ability to predict iAs contamination in private drinking wells and
innovative methods for enhanced removal to reduce iAs. Across Projects, we use a translational approach that
spans in vitro models and cell culture, mouse models, and human samples. Four Cores include the Community
Engagement Core, Data management and Analysis Core (DMAC), Research Experience and Training
Coordination Core (RETCC), and Chemistry and Analytical Core (CAC). The UNC-SRP Director is Dr. Rebecca
Fry, a Biomedical Researcher, who is supported in this role by Deputy Director Dr. Fernando Pardo-Manuel de
Villena (Biomedical Researcher) and Assistant Director, Dr. Michael Aitken (Environmental Engineer). Drs. Fry,
Pardo-Manuel de Villana and Aitken have extensive experience with administration and oversight of large
research efforts, established leadership in successful mentoring, and complementary scientific expertise relevant
to the proposal. Their interdisciplinary expertise and experience contributes significantly to the goal of the
Administrative Core is to foster an environment that stimulates innovative science and ensures that all UNC-
SRP Projects and Cores work toward the overarching theme, “Identifying novel methods to reduce iAs exposure
and elucidating mechanisms underlying iAs-induced metabolic dysfunction with a vision for disease prevention.”
The goal of the Core is achieved through four aims. First, we integrate, coordinate, and monitor UNC-SRP
interdisciplinary research activities focused on iAs reduction and metabolic disease/diabetes prevention.
Second, we convene advisory groups to provide critical guidance on UNC-SRP activities. Third, we develop
effective research translation and communication strategies for UNC-SRP stakeholders related to iAs reduction
and disease prevention. Finally, we provide training and career development opportunities for graduate students
and post-doctoral fellows that foster integration across the Biomedical and Environmental Science research
areas. Combined, these aims ensure a thriving research program bolstered b...

## Key facts

- **NIH application ID:** 9841112
- **Project number:** 1P42ES031007-01
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Rebecca Fry
- **Activity code:** P42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $231,034
- **Award type:** 1
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9841112

## Citation

> US National Institutes of Health, RePORTER application 9841112, Core A: Administrative Core (1P42ES031007-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9841112. Licensed CC0.

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