# Neurocircuitry of acute alcohol intoxication in individuals at familial history risk for alcoholism

> **NIH NIH P60** · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $184,315

## Abstract

Project Summary / Abstract
Having a family history of alcohol use disorder (AUD) increases one's likelihood of developing an AUD. The
mechanisms underlying this risk are unclear, but familial AUD-related premorbid differences in brain circuitry
have been demonstrated. Further, studies comparing the subjective responses to alcohol in family history-
positive and family-history negative (FH+/FH-) individuals indicate that FH+ individuals report more stimulation
and less sedation than FH- individuals, and these effects are seen across the ascending and descending limbs
of the blood alcohol curve (BAC), respectively. These subjective phenotypes are associated with the
perpetuation of alcohol use. However, little is known about concurrent alterations in brain circuitry across the
BAC and the extent to which these alterations, and differing subjective effects, reflect underlying
neurobiological differences in AUD risk. Accordingly, we aim to address this knowledge gap using functional
magnetic resonance imaging techniques. We will compare patterns of functional connectivity in FH+ and FH-
individuals, matched for drinking history, across the BAC during acute alcohol intoxication. Specifically,
functional connectivity magnetic resonance imaging (fcMRI) will be examined in relation to the BAC, using a
90-min scanning protocol in a total of 72 young adults (36 FH+/36 FH-; age 21; groups matched for prior
drinking history). Twenty minutes prior to beverage consumption, a pre-beverage assessment will occur and an
intravenous (IV) line will be placed to allow repeated blood draws. Next, participants will consume a beverage
(0 [placebo], 0.6 g/kg [total alcohol dose]; order counterbalanced between sessions for a within subjects dosing
design) and scanning will begin, including 70 minutes of fcMRI across the BAC. Every 10 minutes throughout
the fcMRI data collection (at the same times blood samples are taken), subjects will also complete a brief
subjective effects questionnaire, so that subjective effects (stimulation, sedation) can be recorded and related
to fcMRI between specific brain regions. Comparing functional connectivity underlying response to acute
alcohol intake across the BAC in the brains of at-risk, compared to lower risk, individuals will provide useful
information about the neurobiology of alcohol's actions and interactive factors associated with abuse liability
(subjective response), which may ultimately inform intervention efforts.

## Key facts

- **NIH application ID:** 9841347
- **Project number:** 5P60AA010760-25
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Bonnie J. Nagel
- **Activity code:** P60 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $184,315
- **Award type:** 5
- **Project period:** — → 2021-02-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9841347

## Citation

> US National Institutes of Health, RePORTER application 9841347, Neurocircuitry of acute alcohol intoxication in individuals at familial history risk for alcoholism (5P60AA010760-25). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9841347. Licensed CC0.

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