# The Biophysics Collaborative Access Team

> **NIH NIH P41** · ILLINOIS INSTITUTE OF TECHNOLOGY · 2020 · $1,158,735

## Abstract

   
DESCRIPTION (provided by applicant): The BioCAT Biotechnology Research Resource operates X-ray beamline 18ID at the Advanced Photon Source, Argonne National Laboratory. Now in its 20th year of operation, it is a mature, productive facility with many capabilities uniqu in the USA, and, arguably, the world. Going forward, we intend to maintain our world-class capabilities in static, time- and spatially-resolved fiber diffraction with beamline enhancements for increased flux and beam quality. A novel high speed, high sensitivity, high spatial resolution pixel array detector will provide an excellent match to the needs of our muscle diffraction program. Also proposed is a versatile micro-diffraction/micro-SAXS instrument that can use one of two Compound Refractive Lenses optimized for either wide- or small-angle fiber crystallography, and continuous flow SAXS experiments. We will implement multimodal scanning micro-diffraction, x-ray florescence microscopy, phase contrast and uv/visible imaging that can be done either singly or in combination with the same instrument on the same samples.   
Developments in time-resolved SAXS will extend available time regimes from 500 ns to seconds with major reductions in sample consumption, by more than order of magnitude, from current capabilities. This will allow a much wider range of biomedical problems to be addressed than previously possible. A new beamline data acquisition and control system will provide a common interface and better data management for all experiments and advanced support for time resolved experiments. Combined refractive index, dynamic light scattering and multi-angle light scattering measurements with SAXS will offer more comprehensive sample characterization on-line for more robust results. A multi-scale modeling effort will allow extracting more information from muscle X-ray diffraction studies. The proposed developments in multi-scale simulations for interpreting single molecule SAXS data will profoundly benefit studies of

## Key facts

- **NIH application ID:** 9841403
- **Project number:** 5P41GM103622-24
- **Recipient organization:** ILLINOIS INSTITUTE OF TECHNOLOGY
- **Principal Investigator:** THOMAS C IRVING
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,158,735
- **Award type:** 5
- **Project period:** 1997-09-30 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9841403

## Citation

> US National Institutes of Health, RePORTER application 9841403, The Biophysics Collaborative Access Team (5P41GM103622-24). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/9841403. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*